protein 790 words KG: S100BPROTEIN
Contents

S100B Protein

🔬 Protein Info
Gene SymbolS100B
Full NameS100 Calcium Binding Protein B
AliasesS100BPROTEIN
Chromosome21q22.3
Protein FamilyS100 EF-hand calcium binding proteins
Functionis a gene encoding a calcium-binding protein of the S100 family, playing crucial roles in neuronal function, astrocyte biology, and neuroinflammation.
Molecular Weight10.5 kDa
Amino Acids92 aa
PathwaysPI3K
UniProt ID[P16401](https://www.uniprot.org/uniprot/P16401)
Ensembl IDENSG00000122574
OMIM176990
GeneCardsS100B
Human Protein AtlasS100B
Associated DiseasesAls, Cardiovascular, Glioma, Inflammation, Ms, Neurodegeneration
InteractionsAdiponectin, ADIPOQ, ALZHEIMER, AMYLOID, AND, APOPTOSIS
SciDEX HypothesesS100B as Active Pathogenic BBB-Disrupting Signal v
KG Connections363 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (17)

Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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