| Gene Symbol | PRKACB |
| Full Name | Protein Kinase cAMP-Activated Catalytic Subunit Beta |
| Aliases | PRKACBPROTEIN |
| Chromosome | 1p31.1 |
| Function | PKA catalytic subunit β (PKA-Cβ) catalyzes phosphate transfer: - cAMP binds to regulatory subunits, releasing catalytic subunits - Free catalytic subunits phosphorylate target proteins on serine/threo |
| Subcellular Localization | </strong></td><td>Cytoplasm, Nucleus</td></tr> |
| Molecular Weight | 40.6 kDa |
| Amino Acids | 361 aa |
| Pathways | Mapk |
| UniProt ID | P22694 |
| Ensembl ID | ENSG00000142831 |
| GeneCards | PRKACB |
| Human Protein Atlas | PRKACB |
| ATP-binding pocket | The canonical kinase active site accommodates ATP in an extended conformation |
| Substrate-binding groove | A hydrophobic groove on the C-lobe recognizes the motif R-R-X-S/T-Φ (where Φ is a hydrophobic residue) |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | CDK1, EGFR, ERBB2, FOXO1, GENES, GNB4 |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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