protein 630 words KG: PNKPPROTEIN
Contents

PNKP Protein - Polynucleotide Kinase 3'-Phosphatase

🔬 Protein Info
Gene SymbolPNKP
Full NamePNKP - Polynucleotide Kinase 3'-Phosphatase
AliasesPage for PNKP Protein
Chromosome19q13.33
Protein TypeGene
Functionis a critical DNA repair enzyme that plays an essential role in maintaining genomic integrity in post-mitotic neurons.
Subcellular Localization** Nucleus, Mitochondria
Molecular Weight47 kDa
Amino Acids515 aa
Exons19
UniProt IDQ96T60
NCBI Gene ID11277
Ensembl IDENSG00000136717
GeneCardsPNKP
Human Protein AtlasPNKP
Associated DiseasesParkinson's disease
InteractionsAND, App, ATM, ATXN3, CANCER, DNA
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
PARP1 Inhibition Therapy
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (2)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with

Knowledge Graph (2 edges)

PNKPPROTEIN associated_with TREM2
PNKPPROTEIN upregulates MHC-I

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