| Gene Symbol | GAP43 |
| Aliases | Neuromodulin |
| Chromosome | 3q13.31 |
| Protein Family | Neuromodulin family |
| Protein Type | Structural Protein |
| Target Class | Structural Protein |
| Function | GAP43 (also known as neuromodulin) is a neuronal phosphoprotein specifically expressed in growing neurons during development and regeneration. |
| Mechanism of Action | Drugs targeting GAP43 would enhance axonal growth cone formation and synaptic plasticity by promoting phosphorylation or membrane translocation of GAP43, thereby facilitating neurite outgrowth and synapse formation. Alternatively, agents could upregulate GAP43 expression to restore neuronal connectivity and compensate for age-related decline in neurodegenerative conditions. |
| Primary Expression | growing ne |
| Subcellular Localization | Plasma membrane, Growth cones, Axon terminals |
| Druggability | Undruggable (0.21) |
| Clinical Stage | Approved |
| Molecular Weight | 23.6 kDa |
| Pathways | Axonal Regeneration, Mitochondrial dynamics / bioenergetics |
| UniProt ID | P17642 |
| NCBI Gene ID | 2596 |
| Ensembl ID | ENSG00000175676 |
| GeneCards | GAP43 |
| Human Protein Atlas | GAP43 |
| Associated Diseases | ALS, Axon Degeneration, glioblastoma, neurodegeneration, ventricular arrhythmias |
| Known Drugs/Compounds | Pituitary Adenylyl Cyclase-Activating Peptide (PACAP), BDNF (Brain-Derived Neurotrophic Factor), Chondroitinase ABC, NSF127 |
| Interactions | ACHE, Actin, ANXIETY, APOPTOSIS, App, ASTROCYTE |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | GAP43-mediated tunneling nanotube stabilization en |
| KG Connections | 392 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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