protein 1,180 words KG: DARS2PROTEIN
Contents

Mitochondrial Aspartyl-tRNA Synthetase

🔬 Protein Info
Gene SymbolDARS2PROTEIN
Full NameMitochondrial Aspartyl-tRNA Synthetase
Protein FamilyAminoacyl-tRNA synthetases, class II
Protein TypeEnzyme
Functionis an essential enzyme that catalyzes the attachment of aspartic acid to its cognate tRNA in mitochondria.
Primary ExpressionHigh in brain, heart, muscle
Molecular Weight~80 kDa (645 amino acids)
Amino Acids645 aa
UniProt IDQ9N1W8
NCBI Gene ID27165
GeneCardsDARS2PROTEIN
Human Protein AtlasDARS2PROTEIN
Associated Diseasesneurodegeneration
InteractionsCDK4, ERK, MYC, PINK1
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (16)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (14)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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