protein 1,775 words KG: CD200PROTEIN
Contents

CD200 Protein

🔬 Protein Info
Gene SymbolCD200
Full NameCD200 Molecule (OX-2 Membrane Glycoprotein)
AliasesCD200 membrane glycoprotein
Chromosome3q12-13
Functionis a widely expressed membrane glycoprotein that serves as a critical immune checkpoint molecule in the central nervous system.
Primary Expressionthe central nervous system:
Molecular Weight47 kDa
Amino Acids269 aa
Exons5
PathwaysMicroglia Activation, Phagocytosis, inflammation, phagocytosis
UniProt ID[P14210](https://www.uniprot.org/uniprot/P14210)
Ensembl IDENSG00000100288
OMIM155730
GeneCardsCD200
Human Protein AtlasCD200
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAND, CD200R1, DIABETIC RETINOPATHY, FGF2, FGF9, IL10
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (11)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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