| Gene Symbol | ATG4B |
| Full Name | Autophagy Related 4B Cysteine Peptidase |
| Chromosome | 2q37.3 |
| Protein Type | Protease |
| Function | encodes a cysteine protease that plays a fundamental role in the autophagy pathway, the cell's primary degradation system for clearing damaged proteins, aggregates, and organelles. |
| Amino Acids | 393 aa |
| UniProt ID | ATG4A |
| NCBI Gene ID | 23192 |
| Ensembl ID | ENSG00000135679 |
| OMIM | 604353 |
| GeneCards | ATG4B |
| Human Protein Atlas | ATG4B |
| Cys74 | Nucleophilic residue in the active site |
| His278 | Catalytic histidine |
| Asp275 | Catalytic aspartate |
| Associated Diseases | Als |
| Known Drugs/Compounds | K33-Branched Ubiquitin Chains |
| Interactions | ALS, AND, APOPTOSIS, App, ATG13, ATG3 |
| KG Connections | 194 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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