| Gene Symbol | APOEPROTEIN |
| Chromosome | 19q13.2 |
| Target Class | Ligand |
| Function | is a 34 kDa secreted glycoprotein that serves as the primary cholesterol transport protein in the brain and plays a central role in lipid metabolism, synaptic repair, and neuroinflammation[@mahley2... |
| Mechanism of Action | Protein-protein interaction modulator or lipid metabolism enhancer |
| Druggability | Medium (0.47) |
| Clinical Stage | Phase II |
| Molecular Weight | 34 kDa |
| GeneCards | APOEPROTEIN |
| Human Protein Atlas | APOEPROTEIN |
| Associated Diseases | AD, Age Of Onset, Aging, alpha-synucleinopathies, Als |
| Known Drugs/Compounds | atherogenic lipoproteins, Crispr, curcumin, CURCUMIN |
| Interactions | A2M, ABC7 transporter, ABCA1, abca2, ABCA2, ABCA7 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Prime Editing Precision Correction of APOE4 to APO Selective APOE4 Degradation via Proteolysis Target Competitive APOE4 Domain Stabilization Peptides (+25 more) |
| KG Connections | 4626 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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