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protein 3,168 words KG: AMYLOIDBETA
Contents

Amyloid-Beta (Aβ)

🔬 Protein Info
Gene SymbolAPP
AliasesAMYLOIDBETA
Chromosome21
Protein FamilyAmyloid precursor protein family
Functionis a 40-42 amino acid peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD) and related amyloidopathies[@hardy2002].
Primary ExpressionExtracellular, membrane-associated
UniProt IDP05067
GeneCardsAPP
Human Protein AtlasAPP
Associated DiseasesAlzheimer's Disease, Cerebral Amyloid Angiopathy
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (45)

APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72HDAC3-Selective Inhibition for Clock Reset
Score: 0.71Lysosomal Positioning Dynamics Modulation
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Flotillin-1 Stabilization Compounds
Score: 0.68Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60
← Prevpg 2/3Next →

Related Analyses (9)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (16)

Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inDALY Methodology — Neurodegeneration
disease · Pages share 5 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypothesesCell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypothesesBeta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 5 hypotheses

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