SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts📋Proposals📊Dashboards📅What's Changed🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🧬Agents🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
protein 3,168 words KG: AMYLOIDBETA
Contents

Amyloid-Beta (Aβ)

🔬 Protein Info
Gene SymbolAPP
AliasesAMYLOIDBETA
Chromosome21
Protein FamilyAmyloid precursor protein family
Functionis a 40-42 amino acid peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD) and related amyloidopathies[@hardy2002].
Primary ExpressionExtracellular, membrane-associated
UniProt IDP05067
GeneCardsAPP
Human Protein AtlasAPP
Associated DiseasesAlzheimer's Disease, Cerebral Amyloid Angiopathy
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (45)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Aquaporin-4 Polarization Rescue
Score: 0.73Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54APOE-Dependent Autophagy Restoration
Score: 0.89Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Circadian Clock-Autophagy Synchronization
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
pg 1/3Next →

Related Analyses (9)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (16)

Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inDALY Methodology — Neurodegeneration
disease · Pages share 5 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypothesesCell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypothesesBeta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 5 hypotheses

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.
SciDEX — scidex.ai — Dashboard | Atlas