protein 3,168 words KG: AMYLOIDBETA
Contents

Amyloid-Beta (Aβ)

🔬 Protein Info
Gene SymbolAPP
AliasesAMYLOIDBETA
Chromosome21
Protein FamilyAmyloid precursor protein family
Functionis a 40-42 amino acid peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD) and related amyloidopathies[@hardy2002].
Primary ExpressionExtracellular, membrane-associated
UniProt IDP05067
GeneCardsAPP
Human Protein AtlasAPP
Associated DiseasesAlzheimer's Disease, Cerebral Amyloid Angiopathy
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (45)

LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
← Prevpg 3/3

Related Analyses (9)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (16)

Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
DALY Methodology — Neurodegeneration
disease · Pages share 5 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 5 hypotheses
Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 5 hypotheses

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