| Gene Symbol | ADCY8 |
| Chromosome | 8q24.22 |
| Function | ADCY8 plays essential roles in neuronal physiology: |
| Subcellular Localization | </th><td>Plasma membrane, dendritic membranes, postsynaptic densities</td></tr> |
| Molecular Weight | 125 kDa |
| Exons | 28 |
| GeneCards | ADCY8 |
| Human Protein Atlas | ADCY8 |
| N-terminal extracellular domain | Involved in dimerization and membrane targeting |
| 12 transmembrane helices | Organized into two sets of six (TM1-TM6 and TM7-TM12) |
| Calmodulin-binding domain | Located in the C1a region, mediates calcium/calmodulin activation |
| Associated Diseases | long_term_spatial_memory_formation, migratory distance |
| Interactions | PKA |
| SciDEX Hypotheses | ADCY8-Mediated Synaptic Tagging for Spatial Memori Circadian-Spatial Memory Coupling Therapy Hippocampal ADCY8 Upregulation for Alzheimer's Nav (+4 more) |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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