Genome resequencing and association with migratory distance

Exploratory Score: 0.850 Price: $0.50 wild peregrine falcon populations Status: proposed

What This Experiment Tests

Exploratory experiment designed to discover new patterns targeting ADCY8 in wild peregrine falcon populations. Primary outcome: identification of genetic variants associated with migratory distance

Description

A genomic study that resequenced 35 genomes from 4 peregrine falcon populations to identify genetic determinants of migratory behavior. The analysis focused on identifying genes associated with population-level differences in migratory distance. The study discovered that the gene ADCY8 (adenylyl cyclase 8) is significantly associated with variation in migratory distance among populations. This gene is involved in cyclic adenosine monophosphate (cAMP) signaling and has been previously implicated in learning and memory processes. The researchers investigated the regulatory mechanisms of ADCY8 and determined that long-term memory was the most likely selective agent driving divergence in this gene among peregrine populations.

TARGET GENE
ADCY8
MODEL SYSTEM
wild peregrine falcon populations
ESTIMATED COST
$0
TIMELINE
0 months
PATHWAY
cAMP signaling pathway, long-term memory formation
SOURCE
extracted_from_pmid_33658718
PRIMARY OUTCOME
identification of genetic variants associated with migratory distance

Scoring Dimensions

Info Gain 0.00 (25%) Feasibility 0.00 (20%) Hyp Coverage 0.00 (20%) Cost Effect. 0.00 (15%) Novelty 0.00 (10%) Ethical Safety 0.00 (10%) 0.850 composite

📖 Wiki Pages

ADCY8 GenegeneADCY8 ProteinproteinMechanismsindexResearchersindex

Protocol

whole genome resequencing of 35 individuals from 4 populations, genome-wide association analysis

Expected Outcomes

identification of candidate genes controlling migratory behavior and distance

Success Criteria

statistically significant association between genetic variants and migratory phenotypes

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