| Gene Symbol | MSH2 |
| Full Name | MutS Homolog 2 |
| Aliases | Page for MSH2 Protein |
| Function | MSH2 is essential for the DNA mismatch repair system: |
| Primary Expression | all brain cell types: - Neurons: High basal expression, constitutive MMR activity - Glia: Lower expression than neurons - |
| Molecular Weight | 104.7 kDa |
| Ensembl ID | ENSG00000116675 |
| GeneCards | MSH2 |
| Human Protein Atlas | MSH2 |
| [Neurons](/entities/neurons) | High basal expression, constitutive MMR activity |
| Glia | Lower expression than neurons |
| Neural progenitors | Active cell cycle, requires MMR |
| Associated Diseases | Als, Cancer, Colorectal Cancer, Gastric Cancer |
| Interactions | LIG1, MLH1, MSH3, MSH6, PMS2 |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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