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mechanism 1,022 words KG: ent-gene-c9882297
Contents

MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-c9882297
Chromosome11q12
Modulate CSF sTREM2 levelsCertain MS4A4A variants are associated with reduced soluble TREM2 in cerebrospinal fluid[@demon2022]
Affect microglial activation statesExpression quantitative trait loci (eQTLs) influence microglial transcriptional programs
Modify disease progressionSome variants correlate with faster cognitive decline
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (26)

KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
← Prevpg 2/2

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completedImmune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archivedWhat are the optimal timing windows for TREM2 agonism vs ant
neurodegeneration · archivedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedDoes SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived

Related Experiments (6)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45Cytochrome Therapeutics
clinical · proposed · Score: 0.40Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (7)

sTREM2 (Soluble TREM2) - Microglial Biomarker
biomarker · Pages share 3 hypothesessTREM2 (Soluble TREM2) - Biomarker
biomarker · Pages share 3 hypothesesal002-trem2-agonist-alzheimers
clinical_trial · Pages share 3 hypothesesTREM2 Gene
gene · Pages share 3 hypothesesTREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-c9882297 data_in benchmark_ot_ad_answer_key:MS4A4A
benchmark_ot_ad_answer_key:MS4A4A data_in ent-gene-c9882297

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