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mechanism 3,753 words KG: calcium
Contents

Calcium Signaling Dysregulation in Parkinson's Disease

⚙ Mechanism Info
Namecalcium
Key Genes/Proteinsalpha_synuclein, amyloid_beta, calcium_channels, HTT, huntingtin, MCU
Related Diseasesactin filament stability, aging, neurodegeneration
Related Pathwayscellular repair pathways
Linked Hypotheses9 hypotheses

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Related Hypotheses (122)

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Score: 0.68
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neurodegeneration · archived

Related Experiments (30)

TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: causesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: modulatesAstrocytes
entity · KG edge: regulatesc9orf72-als-ftd-phenotype-mechanism
general · KG edge: loss_affectsCAMK2A Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

calcium regulates synaptic_transmission
calcium regulates synaptic_plasticity
calcium contributes_to neurodegeneration
oxidative_stress regulates calcium
amyloid_beta regulates calcium
SNCA regulates calcium
HTT regulates calcium
calcium_channels regulates calcium
PSEN1 regulates calcium
endoplasmic_reticulum regulates calcium

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