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mechanism 2,025 words KG: ent-gene-83d99ff1
Contents

FUS Protein in Amyotrophic Lateral Sclerosis

🔬 Protein Info
Gene Symbolent-gene-83d99ff1
N-terminal low-complexity domain (LCD)Prion-like domain involved in phase separation
RNA recognition motif (RRM)Binds RNA sequences
Zinc finger domain (ZF)RNA binding
Nuclear localization signal (NLS)Nuclear import
C-terminal proline-rich regionProtein interactions
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (33)

TREM2-mediated microglial tau clearance enhancement
Score: 0.62Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Vagal Afferent Microbial Signal Modulation
Score: 0.62TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Noradrenergic-Tau Propagation Blockade
Score: 0.71Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Vocal Cord Neuroplasticity Stimulation
Score: 0.52Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
pg 1/2Next →

Related Analyses (30)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedMicroglial subtypes in neurodegeneration — friend vs foe
neuroscience · archived

Related Experiments (6)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90

Knowledge Graph (12 edges)

h-0c9e2166ed targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-0c9e2166ed
h-297a9dcbfa targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-297a9dcbfa
h-a23cc3c8b9 targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-a23cc3c8b9
h-4c4bf4a28f targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-4c4bf4a28f
ent-gene-83d99ff1 participates_in_pathway R-HSA-72163
ent-gene-83d99ff1 participates_in_pathway R-HSA-72203

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