mechanism 2,025 words KG: ent-gene-83d99ff1
Contents

FUS Protein in Amyotrophic Lateral Sclerosis

🔬 Protein Info
Gene Symbolent-gene-83d99ff1
N-terminal low-complexity domain (LCD)Prion-like domain involved in phase separation
RNA recognition motif (RRM)Binds RNA sequences
Zinc finger domain (ZF)RNA binding
Nuclear localization signal (NLS)Nuclear import
C-terminal proline-rich regionProtein interactions
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (33)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
TREM2-Dependent Microglial Senescence Transition
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
← Prevpg 2/2

Related Analyses (30)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · archived

Related Experiments (6)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90

Knowledge Graph (12 edges)

h-0c9e2166ed targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-0c9e2166ed
h-297a9dcbfa targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-297a9dcbfa
h-a23cc3c8b9 targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-a23cc3c8b9
h-4c4bf4a28f targets ent-gene-83d99ff1
ent-gene-83d99ff1 targeted_by h-4c4bf4a28f
ent-gene-83d99ff1 participates_in_pathway R-HSA-72163
ent-gene-83d99ff1 participates_in_pathway R-HSA-72203

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