concept

LYSOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

2Hypotheses

1Analyses

19Outgoing

21Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LYSOSOMES
Key Genes/Proteins	C9ORF72

Pathway Diagram

graph TD
    LYSOSOMES["LYSOSOMES"]
    LYSOSOMES -->|"regulates"| Autophagy["Autophagy"]
    LYSOSOMES -->|"involved_in"| Endocytosis["Endocytosis"]
    LYSOSOMES -->|"involved_in"| Lysosomal_Storage_Disorders["Lysosomal Storage Disorders"]
    LYSOSOMES -->|"causes"| Lysosomal_Storage_Diseases["Lysosomal Storage Diseases"]
    LYSOSOMES -->|"causes"| Neurodegeneration["Neurodegeneration"]
    LYSOSOMES -->|"involved_in"| Amyloid_Beta["Amyloid Beta"]
    LYSOSOMES -->|"involved_in"| Nutrient_Sensing["Nutrient Sensing"]
    TMEM192["TMEM192"] -->|"expressed in"| LYSOSOMES
    Autophagy -->|"involved_in"| LYSOSOMES
    Endocytosis -->|"involved_in"| LYSOSOMES
    Lysosome_Quality_Control["Lysosome Quality Control"] -->|"regulates"| LYSOSOMES
    Autophagosomes["Autophagosomes"] -->|"interacts"| LYSOSOMES
    Phosphatidylinositol_3_Phospha["Phosphatidylinositol 3-Phosphate"] -->|"regulates"| LYSOSOMES
    Lysosome_Membrane_Protein_Regu["Lysosome Membrane Protein Regulation"] -->|"regulates"| LYSOSOMES
    Lysosome_Membrane_Protein_Degr["Lysosome Membrane Protein Degradation"] -->|"involved_in"| LYSOSOMES

Outgoing (19)

Target	Relation	Type	Str
Autophagy	regulates	process	0.95
Autophagy	involved_in	process	0.95
Endocytosis	involved_in	process	0.95
Autophagy	mediates	process	0.90
Hematoma clearance	involved_in	process	0.90
Lysosomal Storage Disorders	involved_in	disease	0.90
Neurodegeneration	associated_with	disease	0.90
Cancer	associated_with	disease	0.90
Lysosomal Storage Diseases	causes	disease	0.90
Neurodegeneration	causes	disease	0.90
Parkinson'S Disease	involved_in	disease	0.88
Signal Transduction	involved_in	process	0.85
Amyloid Beta	involved_in	protein	0.85
Phagosome	interacts_with	cell_type	0.85
Nutrient Sensing	involved_in	process	0.85
Ferroptosis	regulates	process	0.85
DAT	degrades	protein	0.80
autophagy	regulates	process	0.70
distal_axons	limited_trafficking_to	mechanism	0.50

Incoming (21)

Source	Relation	Type	Str
Autophagy	associated_with	process	0.95
Endocytosis	involved_in	process	0.95
Glycerophosphodiesters	associated_with	compound	0.95
Tagless Lysoip	targets	process	0.95
Lysosome Quality Control	regulates	pathway	0.95
TMEM192	expressed_in	protein	0.95
Lipotoxicity	targets	process	0.95
tetrandrine	targets	compound	0.95
SQSTM1	transports	protein	0.95
LAMP1	component_of	protein	0.95
Mdv Cargoes	transports	protein	0.90
Autophagosomes	interacts_with	organelle	0.90
CLN3 Disease	associated_with	disease	0.90
Autophagosomes	associated_with	mechanism	0.85
Phosphatidylinositol 3-Phosphate	regulates	compound	0.85
Peripheral Blood Mononuclear Cells	expressed_in	cell_type	0.85
Induced Pluripotent Stem Cell-Derived Neurons	expressed_in	cell_type	0.80
Lysosome Membrane Protein Regulation	regulates	process	0.80
Lysosome Membrane Protein Degradation	involved_in	process	0.80
ATM	expressed_in	protein	0.70
C9ORF72	regulates	gene	0.64

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Autophagy Activation ULK1/VPS34 (H3): Lipid Routing to Lysos	0.600	neurodegeneration	Does restoring neuronal AMPK activity re
PI3P Generation at Damaged Lysosomes Promotes Membrane Repai	0.530	neurodegeneration	How does controlled lysosomal membrane p

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 10 hypotheses Top: 0.533

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning LYSOSOMES in their description or question text

No additional research found