concept

IGSF8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGSF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

17Outgoing

1Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IGSF8
Key Genes/Proteins	PD1
Related Diseases	Cancer, Cancer Immunotherapy Resistance, Low Antigen Presentation, Low Immune Infiltration
Related Pathways	CRISPR-Cas, Innate Immune Evasion

Pathway Diagram

graph TD
    IGSF8[IGSF8]
    IGSF8 -->|inhibits| NK_Cell_Function[NK Cell Function]
    IGSF8 -->|interacts| KIR3DL2[KIR3DL2]
    IGSF8 -->|interacts| Klra9[Klra9]
    IGSF8 -->|interacts| KLRA9[KLRA9]
    IGSF8 -->|expressed in| Neuronal_Tissues[Neuronal Tissues]
    IGSF8 -->|mediates| Innate_Immune_Evasion[Innate Immune Evasion]
    IGSF8 -.biomarker for.-> Low_Immune_Infiltration[Low Immune Infiltration]
    IGSF8 -.biomarker for.-> Low_Antigen_Presentation[Low Antigen Presentation]
    IGSF8 -->|contributes to| Cancer_Immunotherapy_Resistanc[Cancer Immunotherapy Resistance]
    IGSF8 -->|inhibits| PD1[PD1]
    benchmark_ot_ad_answer_key_IGS[benchmark_ot_ad_answer_key:IGSF8] -->|data_in| IGSF8

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IGSF8	data_in	dataset_row	0.00
KLRA9	interacts_with	receptor	0.95
Klra9	interacts_with	receptor	0.95
KIR3DL2	interacts_with	receptor	0.95
NK Cell Function	inhibits	process	0.95
Neuronal Tissues	expressed_in	cell_type	0.90
Tumor Growth	associated_with	phenotype	0.90
Cancer	associated_with	disease	0.90
Innate Immune Evasion	mediates	mechanism	0.85
Low Antigen Presentation	associated_with	phenotype	0.85
Low Immune Infiltration	biomarker_for	phenotype	0.85
Low Antigen Presentation	biomarker_for	phenotype	0.85
Cancer Immunotherapy Resistance	contributes_to	phenotype	0.85
CRISPR-Cas	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
T cells	expressed_in	cell_type	0.60
PD1	inhibits	gene	0.60

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IGSF8	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGSF8 in their description or question text

No additional research found