| Gene Symbol | HSPA4PROTEIN |
| Full Name | Hsp110 / Hsp70-4 |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Ubiquitous, high in brain, heart, testis |
| Molecular Weight | 94 kDa |
| UniProt ID | P34932 |
| GeneCards | HSPA4PROTEIN |
| Human Protein Atlas | HSPA4PROTEIN |
| ATP-Dependent Cycling | N-terminal ATPase domain regulates substrate binding |
| Hsp70/Hsp40 Collaboration | Forms functional complexes with Hsp70 and Hsp40 |
| Disaggregationase Activity | Can extract proteins from pre-formed aggregates |
| Co-chaperone Interactions | Binds J-domain proteins for substrate delivery |
| Nuclear Import/Export | Facilitates nuclear-cytoplasmic transport of proteins |
| Alzheimer's Disease | Hsp110 may aid in clearing Aβ and tau aggregates |
| Associated Diseases | neurodegeneration |
| Interactions | CDK1, EGFR, ERBB2, FOXO1, GENES, GNB4 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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