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disease 496 words KG: HD
Contents

HD

Disease Info
Alzheimer's Diseaseinteracts_with, co_discussed, associated_with, activates
Amyotrophic Lateral Sclerosis (ALS)associated_with, co_discussed, targets, regulates, interacts_with, activates
Associated GenesAD, BDNF, CDK5, CYP46A1, FUS
KG Connections256 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

No AI portrait yet

Knowledge Graph

Related Hypotheses (38)

Gut-derived butyrate reprograms microglia for amyloid cleara
Score: 0.00Epigenetic Priming Ketone Protocol
Score: 0.88Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA
Score: 0.77METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi
Score: 0.75Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Epigenetic
Score: 0.71HDAC3-Selective Inhibition for Clock Reset
Score: 0.71SCFA Deficiency Drives Microglial Hyperactivation via GPR43/
Score: 0.71SCFA-Producing Bacterial Depletion → Loss of Neuroprotective
Score: 0.70m6A RNA Modification as Address Code for Granule Targeting
Score: 0.70HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism
Score: 0.68Epigenetic Reprogramming of Microglial Memory
Score: 0.65HDAC2 Phospho-Lock Window for Synaptic Gene Silencing
Score: 0.64HDAC6 Selective Inhibition to Restore Acetylation Balance an
Score: 0.64Butyrate-Producing Commensal Depletion Creates Vicious Cycle
Score: 0.63CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delive
Score: 0.62Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift
Score: 0.62HDAC3-Dependent A1 Astrocyte Commitment Window
Score: 0.61Liproxstatin-1 as Mechanism-Validation Tool for Ferroptosis
Score: 0.58
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Knowledge Graph (12 edges)

MIR-196A associated_with HD
38609352 genetic modifier of HD
HD causes HUNTINGTON'S DISEASE
ASTROCYTE associated_with HD
ASTROCYTES associated_with HD
HD associated_with HTT
HD associated_with NEURON
HD associated_with NEURONS
CYP46A1 co_discussed HD
BDNF protects_against HD

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