protein

GPC4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

1Hypotheses

0Analyses

3Outgoing

7Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	GPC4
Pathways	cell communication
GeneCards	GPC4
Human Protein Atlas	GPC4
Associated Diseases	cancer, developmental and neurological disorders
Interactions	RB1, RB1-Fc, RB3
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Glypican-4 Protein (GPC4)

protein · 997 words

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Pathway Diagram

flowchart TD
    N0["GPC4"]
    N1["cell communication"]
    N0 -->|"regulates"| N1
    N2["developmental and neurological disorders"]
    N0 -->|"associated with"| N2
    N3["cancer"]
    N0 -->|"associated with"| N3
    N4["RB1"]
    N4 -->|"interacts with"| N0
    N5["RB3"]
    N5 -->|"interacts with"| N0
    N6["RB1-Fc"]
    N6 -->|"inhibits"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 disease
    class N3 disease
    class N4 protein
    class N5 protein
    class N6 protein

Outgoing (3)

Target	Relation	Type	Str
cell communication	regulates	process	0.70
developmental and neurological disorders	associated_with	disease	0.70
cancer	associated_with	disease	0.70

Incoming (7)

Source	Relation	Type	Str
40060520	enhances	paper	0.90
40883746	induce microglial expression of	paper	0.90
40883746	enhances	paper	0.90
40883746	enhances microglia phagocytosis of	paper	0.90
RB1	interacts_with	protein	0.70
RB3	interacts_with	protein	0.70
RB1-Fc	inhibits	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Con	0.583	neurodegeneration	What are the specific molecular determin

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GPC4 in their description or question text

No additional research found