gene 1,646 words KG: STK4
Contents

STK4 — Serine/Threonine Kinase 4

🧬 Gene Info
Gene SymbolSTK4
Full NameSerine/Threonine Kinase 4
AliasesMST1 kinase in Hippo signaling pathway
Chromosome20q13.12
Protein FamilySTE20 family, Hippo pathway
Protein TypeSerine/Threonine Kinase
Functionis a critical component of the Hippo signaling pathway.
Amino Acids491 aa
UniProt IDQ13043
NCBI Gene ID6789
Ensembl IDENSG00000101109
OMIM604472
GeneCardsSTK4
Human Protein AtlasSTK4
N-terminal kinase domainCatalytic serine/threonine kinase activity (~300 amino acids)
Associated Diseasesneurodegeneration
KG Connections6 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (4)

Neurodegeneration
disease · KG edge: implicated_in
DNAJB12 — DnaJ Heat Shock Protein Family (Hsp40) Member
gene · KG edge: regulates
RB1CC1 Gene
gene · KG edge: regulates
SCN4B Gene - Sodium Voltage-Gated Channel Beta Subunit
gene · KG edge: regulates

Knowledge Graph (6 edges)

DNAJB12 regulates STK4
RB1CC1 regulates STK4
SCN4B regulates STK4
STK4 activates Anxiety
STK4 regulates Ms
STK4 activates Depression

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...