| Gene Symbol | SLIT2 |
| Full Name | Slit Guidance Ligand 2 |
| Chromosome | 4p15.1 |
| Function | is a secreted protein that functions as the ligand for Roundabout (ROBO) receptors, mediating repulsive axon guidance and cell migration during development. |
| Primary Expression | hippocampal neurons |
| Amino Acids | 1529 aa |
| Exons | 36 |
| GeneCards | SLIT2 |
| Human Protein Atlas | SLIT2 |
| N-terminal signal peptide | Directs secretion |
| Leucine-rich repeats (LRRs) | Mediate ROBO binding (approximately 20 LRRs in the N-terminal region) |
| C-terminal cysteine-rich domain | Receptor interaction and dimerization |
| C-terminal coiled-coil region | Protein-protein interactions |
| Isoform 1 | Full-length (1529 aa) - predominant brain expression |
| Isoform 2 | Truncated N-terminus - secreted form |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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