gene 1,581 words KG: SLIT1
Contents

SLIT1 Gene - Slit Guidance Ligand 1

🧬 Gene Info
Gene SymbolSLIT1
Full NameSlit Guidance Ligand 1
Chromosome10q24.1
Protein FamilySlit family
Functionencodes a large secreted extracellular matrix protein that functions as the primary ligand for Roundabout (ROBO) receptors.
Amino Acids564 aa
Exons36
UniProt IDQ9NY64
NCBI Gene ID6588
Ensembl IDENSG00000107829
GeneCardsSLIT1
Human Protein AtlasSLIT1
Large coding regionSingle large exon encoding the majority of the protein
Multiple protein domainsIncluding leucine-rich repeats (LRRs), EGF-like domains, and laminin G domains
Alternative splicingVarious isoforms with different expression patterns
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Quantum Coherence Disruption in Cellular Communication
Score: 0.63

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Alpha-Synuclein Seeding Assays (RT-QuIC and PMCA)
biomarker · Pages share 3 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 3 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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