gene

SLC7A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC7A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

5Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for SLC7A2 — Solute Carrier Family 7 Member 2 ( cationic amino acid transporter 2)

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🧬 Gene Info

Gene Symbol	SLC7A2
Full Name	Solute Carrier Family 7 Member 2
Aliases	cationic amino acid transporter 2
Chromosome	8p22
Function	is a membrane protein that mediates the transport of cationic amino acids across cell membranes[@closs1996].
Primary Expression	neurons, astrocytes, microglia, and endothelial cells of the blood-brain barrier[@bertz2014] - Kidney: High expression in renal tubular cells[@sil
Molecular Weight	70 kDa
Amino Acids	630 aa
Pathways	Interaction
GeneCards	SLC7A2
Human Protein Atlas	SLC7A2
Brain	Expressed in neurons, astrocytes, microglia, and endothelial cells of the blood-brain barrier[@bertz2014]
Kidney	High expression in renal tubular cells[@silbernagl2003]
Liver	Moderate expression in hepatocytes
Lung	Detected in alveolar epithelial cells
Associated Diseases	neurodegeneration
Interactions	MTORC1
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC7A2 — Solute Carrier Family 7 Member 2 ( cationic amino acid transporter 2)

gene · 1768 words

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Pathway Diagram

flowchart TD
    SLC7A2(["SLC7A2"])
    Diabetes["Diabetes"]
    Als["Als"]
    MTORC1(["MTORC1"])
    Mtor["Mtor"]
    Cell_Cycle["Cell Cycle"]
    neurodegeneration["neurodegeneration"]

    SLC7A2 -->|"activates"| Diabetes
    SLC7A2 -.->|"inhibits"| Als
    SLC7A2 -->|"activates"| MTORC1
    SLC7A2 -->|"activates"| Mtor
    SLC7A2 -->|"activates"| Cell_Cycle
    SLC7A2 -->|"implicated in"| neurodegeneration

    style SLC7A2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Diabetes	activates	disease	0.65
Als	inhibits	disease	0.65
MTORC1	activates	gene	0.60
Mtor	activates	pathway	0.60
Cell Cycle	activates	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
genes-slc7a2	linked_to	wiki	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC7A2 in their description or question text

No additional research found