| Gene Symbol | PDE11A |
| Full Name | Phosphodiesterase 11A |
| Chromosome | 2q31.1 |
| Function | The enzyme has a higher affinity for cGMP (Km ~100 nM) compared to cAMP (Km ~1 μM) [5]. |
| Subcellular Localization | s and regulatory properties [3]. The enzyme has emerged as a potential therapeutic target for neurodegenerative diseases |
| Ensembl ID | ENSG00000128605 |
| GeneCards | PDE11A |
| Human Protein Atlas | PDE11A |
| PDE11A1 | Full-length enzyme with N-terminal regulatory domain |
| PDE11A2 | Truncated isoform lacking the N-terminal domain |
| PDE11A3 | Testis-specific isoform |
| PDE11A4 | Brain and peripheral tissue isoform |
| Associated Diseases | Als, Sleep Duration |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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