gene 1,606 words KG: OTOF
Contents

OTOF (Otoferlin)

🧬 Gene Info
Gene SymbolOTOF
Full NameOtoferlin
Chromosome2p23.3
Functionencodes a large transmembrane protein belonging to the ferlin family that is essential for synaptic vesicle exocytosis at the inner hair cell ribbon synapse of the cochlea.
Primary ExpressionInner ear, brain, pancreas, testis
Molecular Weight600 kDa
Amino Acids380 aa
Exons48
PathwaysExocytosis
UniProt IDQ9NZM4
NCBI Gene ID9381
Ensembl IDENSG00000137860
OMIM603681
GeneCardsOTOF
Human Protein AtlasOTOF
Associated DiseasesAging, Als, Ms
KG Connections7 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (3)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Arginine Methylation Enhancement Therapy
Score: 0.65
Glycosaminoglycan Template Disruption Approach
Score: 0.60

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (5)

Neurodegeneration
disease · KG edge: implicated_in
GCAT — Glycerol-3-Phosphate O-Acetyltransferase
gene · KG edge: associated_with
SNAP29 — Synaptosomal-Associated Protein 29
gene · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (7 edges)

SNAP29 associated_with OTOF
GCAT associated_with OTOF
OTOF regulates Als
OTOF associated_with Ms
OTOF activates Exocytosis
OTOF associated_with Als
OTOF associated_with Aging

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