| Gene Symbol | NUP153 |
| Full Name | Nucleoporin 153 |
| Chromosome | 6p22.3 |
| Function | encodes a 1,475-amino acid protein with a molecular weight of approximately 153 kDa. |
| Primary Expression | post-mitotic neurons, where NPCs are extraordinarily long-lived |
| Molecular Weight | 153 kDa |
| Amino Acids | 475 aa |
| UniProt ID | P49790 |
| NCBI Gene ID | 9972 |
| Ensembl ID | ENSG00000124789 |
| OMIM | 603948 |
| GeneCards | NUP153 |
| Human Protein Atlas | NUP153 |
| mRNA export | NUP153 interacts with the TREX-2/GANP mRNA export complex and is required for efficient export of poly(A)+ RNA, including transcripts encoding synaptic proteins |
| RNA foci sequestration | Sense and antisense repeat RNA foci sequester RNA-binding proteins including RANGAP1 and NUP153-interacting transport factors, disrupting the Ran-GTP gradient essential for directional transport |
| Associated Diseases | Alzheimer's Disease, Huntington's Disease |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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