| Gene Symbol | NEU1 |
| Function | NEU1 encodes neuraminidase 1, also known as sialidase 1, a lysosomal enzyme that cleaves terminal sialic acid residues from glycoproteins, glycolipids, and oligosaccharides. |
| Primary Expression | neurons throughout the cortex, hippocampus, basal ganglia, and cerebellum |
| Subcellular Localization | and stability in the lysosome |
| Ensembl ID | ENSG00000105694 |
| GeneCards | NEU1 |
| Human Protein Atlas | NEU1 |
| Glycoprotein degradation | Cleaving sialic acid residues to expose underlying sugars for further hydrolysis |
| Lysosomal function | Essential for proper lysosomal enzyme activity and autophagy |
| Cell surface remodeling | Modifying glycoconjugates on the cell surface |
| Immune regulation | Influencing immune cell function through modification of surface receptors |
| Liver | Highest expression |
| Brain | Neurons, astrocytes, microglia |
| Kidney | Tubular epithelial cells |
| Associated Diseases | neurodegeneration |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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