| Gene Symbol | KCNT1 |
| Full Name | Potassium Sodium-Activated Channel Subfamily T Member 1 / Slack |
| Aliases | KCNT1/Slack gene |
| Chromosome | 9q34.3 |
| Protein Type | Channel |
| Function | KCNT1/Slack channels have important neuronal functions |
| Primary Expression | the brain, particularly in the cortex, hippocampus, and thalamus<sup>[1]</sup> |
| UniProt ID | [Q7RTV0](https://www.uniprot.org/uniprot/Q7RTV0) |
| Ensembl ID | ENSG00000107140 |
| GeneCards | KCNT1 |
| Human Protein Atlas | KCNT1 |
| Potassium conductance | Provides outward K+ current activated by intracellular Na+, helping to repolarize neurons after action potentials<sup>[3]</sup> |
| Neuronal excitability | Regulates resting membrane potential and firing patterns, particularly in fast-firing neurons<sup>[4]</sup> |
| Sodium sensing | Activated by increases in intracellular sodium, serving as a sensor for metabolic stress<sup>[5]</sup> |
| Neuroprotection | May provide protection against sodium overload during ischemia or excitotoxicity<sup>[6]</sup> |
| Associated Diseases | neurodegeneration |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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