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gene 652 words KG: ERCC2
Contents

ERCC2 Gene - Excision Repair Cross-Complementation Group 2

🧬 Gene Info
Gene SymbolERCC2
Full NameExcision Repair Cross-Complementation Group 2
AliasesPage for ERCC2 Gene, Page for ERCC2 Protein (XPD)
Chromosome19q13.32
Protein TypeTranscription Factor
FunctionIt functions as the 5' to 3' helicase subunit within the TFIIH complex (Core TFIIH).
Molecular Weight87 kDa
Amino Acids760 aa
UniProt IDP18080
NCBI Gene ID2075
Ensembl IDENSG00000104881
OMIM278720
GeneCardsERCC2
Human Protein AtlasERCC2
Associated DiseasesAls, Alzheimer
InteractionsCANCER
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (7)

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47CYP46A1 Overexpression Gene Therapy
Score: 0.92Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: associated_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_withAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: contributes_toAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_withAlzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

UBIQUITIN contributes_to ERCC2
NBR1 associated_with ERCC2
APOE associated_with ERCC2
ERCC2 associated_with APOE
APOE co_expressed_with ERCC2
NEURODEGENERATION contributes_to ERCC2
ERCC2 activates CANCER
ERCC2 contributes_to AUTOPHAGY
ERCC2 associated_with Als
ERCC2 activates Cancer

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