| Gene Symbol | CASK |
| Full Name | Calcium/Calmodulin-Dependent Serine Protein Kinase |
| Protein Type | Kinase |
| Function | CASK (Calcium/Calmodulin-dependent Serine Protein Kinase) is a multidomain scaffolding protein that plays a critical role in synaptic organization and neuronal development. |
| Subcellular Localization | postsynaptic densities and presynaptic terminals |
| Molecular Weight | 105 kDa |
| Amino Acids | 926 aa |
| Pathways | MAPK signaling |
| Ensembl ID | ENSG00000147044 |
| GeneCards | CASK |
| Human Protein Atlas | CASK |
| Synaptic scaffolding | CASK binds to multiple synaptic proteins including PSD-95, SAP97, and Synaptic GTPase-activating protein (SynGAP) |
| Receptor anchoring | It anchors NMDA and AMPA receptors at postsynaptic membranes |
| Gene regulation | CASK interacts with transcription factors (including T-brain-1/Tbr1) to regulate gene expression during neuronal development |
| Synaptic vesicle trafficking | Through interactions with MINT1/X11, CASK regulates presynaptic function |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | SNAP-25, SNARE |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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