Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLOCK/ULK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CLOCK/ULK1 |
| Key Genes/Proteins | CHR2/BDNF, CLOCK, CRH, DRD2, DRD2/SNCA, FOXP3/TGFB1 |
| Related Diseases | neurodegeneration |
| Related Pathways | autophagy |
graph TD
CLOCK_ULK1[CLOCK/ULK1]
CLOCK_ULK1 -->|promoted: Circadian-Synchronized Proteostasis Enhancement| neurodegeneration[neurodegeneration]
CLOCK_ULK1 -->|debate_co_mention| CRH[CRH]
CLOCK_ULK1 -->|debate_co_mention| DRD2[DRD2]
CLOCK_ULK1 -->|debate_co_mention| DRD2_SNCA[DRD2/SNCA]
CLOCK_ULK1 -->|debate_co_mention| FOXP3_TGFB1[FOXP3/TGFB1]
CLOCK_ULK1 -->|co_associated_with| NR3C1_CRH_TNFA[NR3C1/CRH/TNFA]
CLOCK_ULK1 -->|co_associated_with| PDGFRB_ANGPT1[PDGFRB/ANGPT1]
CLOCK_ULK1 -->|co_associated_with| PPARGC1A_PRKAA1[PPARGC1A/PRKAA1]
autophagy[autophagy] -->|activates| CLOCK_ULK1
CHR2_BDNF[CHR2/BDNF] -->|debate_co_mention| CLOCK_ULK1
CLOCK[CLOCK] -->|debate_co_mention| CLOCK_ULK1
benchmark_ot_ad_answer_key_CLO[benchmark_ot_ad_answer_key:CLOCK/ULK1] -->|data_in| CLOCK_ULK1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CLOCK/ULK1 | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.58 |
| DRD2 | debate_co_mention | gene | 0.45 |
| DRD2/SNCA | debate_co_mention | gene | 0.45 |
| FOXP3/TGFB1 | debate_co_mention | gene | 0.45 |
| CRH | debate_co_mention | gene | 0.45 |
| NR3C1/CRH/TNFA | co_associated_with | gene | 0.40 |
| PDGFRB/ANGPT1 | co_associated_with | gene | 0.40 |
| FOXP3/TGFB1 | co_associated_with | gene | 0.40 |
| PPARGC1A/PRKAA1 | co_associated_with | gene | 0.40 |
| DRD2/SNCA | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian-Synchronized Proteostasis Enhancement | 0.744 | neurodegeneration | Digital biomarkers and AI-driven early d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| Experiment Index | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Macroautophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| N-of-1 Clinical Trial Design for CBS/PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Scoring Methodology | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of r [PMID:37086572] | Chunli Yang, Ziwei Deng, Qihang Zeng, Xi | Biochemical and biophysical re | 2023 | 1 |
| Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Agin [PMID:41521387] | ["Milan M", "Troyano-Rodriguez E", "Ihuo | Aging cell | 2026 | 0 |
| Cellular Models of Aging and Senescence. [PMID:40862757] | Kim B, Lee DI, Basisty N, Dai DF | Cells | 2025 | 0 |
| Circadian clock genes and cell survival in bipolar disorder: Insights into lithi [PMID:39995020] | ["Mishra H", "Wei H", "LeRoux M", "Ko D" | The FEBS journal | 2025 | 0 |
| Rapamycin mitigates neurotoxicity of fluoride and aluminum by activating autopha [PMID:40119168] | ["Tao D", "Xia Y", "Liao Q", "Yang X", " | Scientific reports | 2025 | 0 |
| Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Pers [PMID:41287625] | Namgyal D, Lim CS | Nature and science of sleep | 2025 | 0 |
| Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 [PMID:40202498] | ["Gu J", "Yang M", "Zhang L", "Liu Y", " | The Journal of cell biology | 2025 | 0 |
| Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the bra [PMID:40506775] | ["Kong J", "Xie Y", "Fan R", "Wang Q", " | European journal of medical re | 2025 | 0 |
| Circadian clock genes and insomnia: molecular mechanisms and therapeutic implica [PMID:41123484] | Ren Q, Gu M, Fan X | Ann Med | 2025 | 0 |
| Orexin-A and Circadian Disruption in Alzheimer's Disease: Implications for Amylo [PMID:41335394] | ["Singh R", "Kaur V", "Ash A", "Singh M" | Molecular neurobiology | 2025 | 0 |
| Differential contributions of circadian clock genes to cell survival in bipolar [PMID:38746315] | ["Mishra H", "Wei H", "LeRoux M", "Ko I" | Research square | 2024 | 0 |
| Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by [PMID:39596274] | ["Rokad D", "Harischandra D", "Samidurai | International journal of molec | 2024 | 0 |
| Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond. [PMID:37887295] | ["Statsenko Y", "Kuznetsov N", "Morozova | Cells | 2023 | 0 |
| Contributions of circadian clock genes to cell survival in fibroblast models of [PMID:37126998] | ["Mishra H", "Wei H", "Rohr K", "Ko I", | European neuropsychopharmacolo | 2023 | 0 |
| Guidelines for the use and interpretation of assays for monitoring autophagy (4t [PMID:33634751] | ["Klionsky D", "Abdel-Aziz A", "Abdelfat | Autophagy | 2021 | 0 |
| Defining circadian disruption in neurodegenerative disorders. [PMID:34596047] | ["Colwell C"] | The Journal of clinical invest | 2021 | 0 |
| Obestatin attenuated methamphetamine-induced PC12 cells neurotoxicity via inhibi [PMID:31726888] | ["Foroughi K", "Jahanbani S", "Khaksari | Human & experimental toxicolog | 2020 | 0 |
| Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modul [PMID:30943415] | ["Xu F", "Kula-Eversole E", "Iwanaszko M | Cell reports | 2019 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CLOCK/ULK1 in their description or question text
No additional research found