Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPARGC1A/PRKAA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PPARGC1A/PRKAA1 |
| Key Genes/Proteins | CHR2/BDNF, CLOCK/ULK1, DRD2/SNCA, FOXP3/TGFB1, NR3C1/CRH/TNFA, PDGFRB |
| Related Diseases | neurodegeneration |
graph TD
PPARGC1A_PRKAA1[PPARGC1A/PRKAA1]
PPARGC1A_PRKAA1 -->|promoted: Digital Twin-Guided Metabolic Reprogramming| neurodegeneration[neurodegeneration]
PPARGC1A_PRKAA1 -->|debate_co_mention| PRKAA1[PRKAA1]
PPARGC1A_PRKAA1 -->|debate_co_mention| RANK[RANK]
PPARGC1A_PRKAA1 -->|debate_co_mention| ULK1[ULK1]
PPARGC1A_PRKAA1 -->|data_in| benchmark_ot_ad_answer_key_PPA[benchmark_ot_ad_answer_key:PPARGC1A/PRKAA1]
NR3C1_CRH_TNFA[NR3C1/CRH/TNFA] -->|debate_co_mention| PPARGC1A_PRKAA1
PDGFRB[PDGFRB] -->|debate_co_mention| PPARGC1A_PRKAA1
PDGFRB_ANGPT1[PDGFRB/ANGPT1] -->|debate_co_mention| PPARGC1A_PRKAA1
PPARGC1A[PPARGC1A] -->|debate_co_mention| PPARGC1A_PRKAA1
CLOCK_ULK1[CLOCK/ULK1] -->|co_associated_with| PPARGC1A_PRKAA1
DRD2_SNCA[DRD2/SNCA] -->|co_associated_with| PPARGC1A_PRKAA1
FOXP3_TGFB1[FOXP3/TGFB1] -->|co_associated_with| PPARGC1A_PRKAA1
CHR2_BDNF[CHR2/BDNF] -->|co_associated_with| PPARGC1A_PRKAA1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PPARGC1A/PRKAA1 | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.61 |
| PRKAA1 | debate_co_mention | gene | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| ULK1 | debate_co_mention | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PPARGC1A/PRKAA1 | data_in | dataset_row | 0.00 |
| NR3C1/CRH/TNFA | debate_co_mention | gene | 0.45 |
| PDGFRB | debate_co_mention | gene | 0.45 |
| PDGFRB/ANGPT1 | debate_co_mention | gene | 0.45 |
| PPARGC1A | debate_co_mention | gene | 0.45 |
| NR3C1/CRH/TNFA | co_associated_with | gene | 0.40 |
| PDGFRB/ANGPT1 | co_associated_with | gene | 0.40 |
| CHR2/BDNF | co_associated_with | gene | 0.40 |
| CLOCK/ULK1 | co_associated_with | gene | 0.40 |
| DRD2/SNCA | co_associated_with | gene | 0.40 |
| FOXP3/TGFB1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Digital Twin-Guided Metabolic Reprogramming | 0.550 | neurodegeneration | Digital biomarkers and AI-driven early d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | completed | $100,000 |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Animal Model Comparison for Neurodegenerative Disease Therapeutics | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Index | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Lifestyle Intervention Mechanisms in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $430,000 |
| Metabolic Syndrome-Parkinson's Disease Axis Clinical Trial | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Parkinson's Disease Subtype Classification — Precision Medicine Approa | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Metformin restores mitochondrial bioenergetics and redox homeostasis through mod [PMID:40327990] | Brondani M, Ribeiro RT, Pinheiro CV, Hof | Biomed Pharmacother | 2025 | 1 |
| System biology-based assessment of the molecular mechanism of epigallocatechin g [PMID:40664965] | Fanai HL, Chand J, Ahmad SF, Attia SM, E | Sci Rep | 2025 | 1 |
| Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586] | Prashantha Kumar BR, Kumar AP, Jose JA, | Neurochem Int | 2020 | 1 |
| The pharmacogenetics of type 2 diabetes: a systematic review. [PMID:24558078] | Nisa M Maruthur, Matthew O Gribble, Wend | Diabetes care | 2014 | 1 |
| Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614] | ["Jin H", "Xue B", "Chen X", "Ma T", "Ma | Environmental pollution (Barki | 2025 | 0 |
| PSMD4 Alleviates Aβ₁₋₄₂-Induced Mitochondrial Dysfunction and Oxidative Stress v [PMID:41269417] | Yuan M, Han XJ, Luo CQ, Pan HL, Zhou HY | Mol Neurobiol | 2025 | 0 |
| p75NTR Modulation by LM11A-31 Counteracts Oxidative Stress and Cholesterol Dysme [PMID:41045381] | ["Pensabene D", "Martella N", "Scavo G", | Neurochemical research | 2025 | 0 |
| PSMD4 Alleviates Aβ₁₋₄₂-Induced Mitochondrial Dysfunction and Oxidative Stress v [PMID:41269417] | ["Yuan M", "Han X", "Luo C", "Pan H", "Z | Molecular neurobiology | 2025 | 0 |
| Lipid metabolism and immune crosstalk in fish gut-liver axis: Insights from SOCS [PMID:40914506] | Altaf F, Wu N, Shi M, Li J, Shan J, Su L | Fish & shellfish immunology | 2025 | 0 |
| Cordycepin Modulates Microglial M2 Polarization Coupled with Mitochondrial Metab [PMID:38889331] | ["Zhong X", "Gong S", "Meng L", "Yao W", | Advanced science (Weinheim, Ba | 2024 | 0 |
| Inflammation in atherosclerosis: pathophysiology and mechanisms. [PMID:39528464] | Ajoolabady A, Pratico D, Lin L, Mantzoro | Cell death & disease | 2024 | 0 |
| Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, an [PMID:38501315] | Huang SY, Zhang YR, Guo Y, Du J, Ren P, | Alzheimer's & dementia : the j | 2024 | 0 |
| Metabolic reprogramming in inflammatory microglia indicates a potential way of t [PMID:37586250] | ["Sangineto M", "Ciarnelli M", "Cassano | Redox biology | 2023 | 0 |
| Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and [PMID:34822940] | ["Liu H", "Han W", "Zhu S", "Li Z", "Liu | Food and chemical toxicology : | 2021 | 0 |
| Covering the Role of PGC-1α in the Nervous System. [PMID:35011673] | Kuczynska Z, Metin E, Liput M, Buzanska | Cells | 2021 | 0 |
| A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer [PMID:31257151] | ["Baik S", "Kang S", "Lee W", "Choi H", | Cell metabolism | 2019 | 0 |
| Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigm [PMID:30249643] | ["Xu L", "Kong L", "Wang J", "Ash J"] | Proceedings of the National Ac | 2018 | 0 |
| Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1α. [PMID:30201263] | ["Niu Z", "Tang J", "Ren Y", "Feng W"] | Biochemical and biophysical re | 2018 | 0 |
| Promotion of mitochondrial biogenesis by necdin protects neurons against mitocho [PMID:26971449] | ["Hasegawa K", "Yasuda T", "Shiraishi C" | Nature communications | 2016 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PPARGC1A/PRKAA1 in their description or question text
No additional research found