| MRI (DWI/FLAIR) | Cortical ribboning pattern and bilateral basal ganglia or thalamic hyperintensities are highly characteristic of sCJD. |
| EEG | Periodic sharp-wave complexes occur in ~60–70% of sCJD but are absent in vCJD. |
| CSF biomarkers | 14-3-3 protein is elevated; total tau is markedly elevated (often >1300 pg/mL); brain-derived tau and phospho-tau ratios aid differential diagnosis from Alzheimer's disease. [PMID:37858957] |
| Neurofilament light chain (NfL) | Blood and CSF NfL are substantially elevated in CJD compared to other dementias, reflecting rapid neuronal injury. [PMID:37264656] |
| Anti-PrP^Sc^ antibodies | Targeting misfolded PrP oligomers or surface PrP^C^ to reduce conversion substrate |
| Small molecule stabilizers | Compounds that stabilize the native PrP^C^ conformation against conversion |
| KG Connections | 29 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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