Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHR2/BDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CHR2/BDNF |
| Key Genes/Proteins | CLOCK, CLOCK/ULK1, CRH, DRD2, DRD2/SNCA, FOXP3/TGFB1 |
| Related Diseases | neurodegeneration |
| Related Pathways | autophagy |
graph TD
CHR2_BDNF[CHR2/BDNF]
CHR2_BDNF -->|debate_co_mention| CLOCK[CLOCK]
CHR2_BDNF -->|debate_co_mention| CLOCK_ULK1[CLOCK/ULK1]
CHR2_BDNF -->|debate_co_mention| CRH[CRH]
CHR2_BDNF -->|debate_co_mention| DRD2[DRD2]
CHR2_BDNF -->|co_associated_with| DRD2_SNCA[DRD2/SNCA]
CHR2_BDNF -->|co_associated_with| FOXP3_TGFB1[FOXP3/TGFB1]
CHR2_BDNF -->|co_associated_with| NR3C1_CRH_TNFA[NR3C1/CRH/TNFA]
CHR2_BDNF -->|co_associated_with| PDGFRB_ANGPT1[PDGFRB/ANGPT1]
CHR2_BDNF -->|co_associated_with| PPARGC1A_PRKAA1[PPARGC1A/PRKAA1]
autophagy[autophagy] -->|debate_co_mention| CHR2_BDNF
benchmark_ot_ad_answer_key_CHR[benchmark_ot_ad_answer_key:CHR2/BDNF] -->|data_in| CHR2_BDNF| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CHR2/BDNF | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| DRD2 | debate_co_mention | gene | 0.45 |
| CLOCK | debate_co_mention | gene | 0.45 |
| CLOCK/ULK1 | debate_co_mention | gene | 0.45 |
| CRH | debate_co_mention | gene | 0.45 |
| PDGFRB/ANGPT1 | co_associated_with | gene | 0.40 |
| PPARGC1A/PRKAA1 | co_associated_with | gene | 0.40 |
| CLOCK/ULK1 | co_associated_with | gene | 0.40 |
| DRD2/SNCA | co_associated_with | gene | 0.40 |
| FOXP3/TGFB1 | co_associated_with | gene | 0.40 |
| NR3C1/CRH/TNFA | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CHR2/BDNF | data_in | dataset_row | 0.00 |
| autophagy | debate_co_mention | pathway | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Vocal Cord Neuroplasticity Stimulation | 0.515 | neurodegeneration | Digital biomarkers and AI-driven early d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Neural Stem Cell Therapy for Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neuron type-specific optogenetic stimulation for differential stroke recovery in [PMID:38825647] | Kim RG, Cho J, Park JY, Kim YR, Lee MC, | Exp Mol Med | 2024 | 1 |
| Optogenetic control of nerve growth. [PMID:25982506] | Park S, Koppes RA, Froriep UP, Jia X, Ac | Sci Rep | 2015 | 1 |
| Optogenetic approaches for neural tissue regeneration: A review of basic optogen [PMID:39995064] | ["Eldar D", "Albert S", "Tatyana A", "Ga | Neural regeneration research | 2026 | 0 |
| A wireless optogenetic stimulation system for long-term function evaluation of m [PMID:41027946] | ["Zhou M", "Yan B", "Yang F", "Chen C", | Nature communications | 2025 | 0 |
| Neural Circuit Mapping and Neurotherapy-Based Strategies. [PMID:40715588] | ["Marei H"] | Cellular and molecular neurobi | 2025 | 0 |
| Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasti [PMID:39662631] | ["Chen Y", "Mao L", "Zhou Q", "Bai D", " | Brain research bulletin | 2025 | 0 |
| Advances in sciatic nerve regeneration: A review of contemporary techniques. [PMID:40475697] | ["Ali S", "Sun M", "Khan M", "Qiang F"] | Regenerative therapy | 2025 | 0 |
| Untitled [PMID:38753056] | ["Wang H", "Huang Z", "Lou S", "Li W", " | Chemical research in toxicolog | 2024 | 0 |
| Electrical Stimulation: How It Works and How to Apply It. [PMID:38972685] | ["Senger J", "Power H", "Moore A"] | Hand clinics | 2024 | 0 |
| Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced [PMID:39561026] | ["Chen B", "Sun Y", "Sun H", "Cong N", " | ACS nano | 2024 | 0 |
| Enhancing Motor and Sensory Axon Regeneration after Peripheral Nerve Injury Usin [PMID:36555724] | ["Ecanow A", "Berglund K", "Carrasco D", | International journal of molec | 2022 | 0 |
| The impact of acupuncture on neuroplasticity after ischemic stroke: a literature [PMID:36439200] | ["Qin S", "Zhang Z", "Zhao Y", "Liu J", | Frontiers in cellular neurosci | 2022 | 0 |
| Co-transplantation of Schwann cells and neural stem cells in the laminin-chitosa [PMID:33130983] | ["Li Y", "Men Y", "Wang B", "Chen X", "Y | Journal of materials science. | 2020 | 0 |
| Generation of Functional Human 3D Cortico-Motor Assembloids. [PMID:33333020] | ["Andersen J", "Revah O", "Miura Y", "Th | Cell | 2020 | 0 |
| Functional regeneration of the transected recurrent laryngeal nerve using a coll [PMID:27558932] | ["Wang B", "Yuan J", "Chen X", "Xu J", " | Scientific reports | 2016 | 0 |
| Chronic activation of the D156A point mutant of Channelrhodopsin-2 signals apopt [PMID:27809305] | ["Perny M", "Muri L", "Dawson H", "Klein | Cell death & disease | 2016 | 0 |
| Enduring high-efficiency in vivo transfection of neurons with non-viral magnetop [PMID:25680542] | ["Soto-S\u00e1nchez C", "Mart\u00ednez-N | Nanomedicine : nanotechnology, | 2015 | 0 |
| Induced unilateral vocal fold paralysis and recovery rapidly modulate brain area [PMID:21051193] | ["Joshi A", "Jiang Y", "Stemple J", "Arc | Journal of voice : official jo | 2011 | 0 |
| Upper aerodigestive tract neurofunctional mechanisms: lifelong evolution and exe [PMID:21910155] | ["Robbins J"] | Head & neck | 2011 | 0 |
| Gene therapy for laryngeal paralysis. [PMID:17388235] | ["Shiotani A", "Saito K", "Araki K", "Mo | The Annals of otology, rhinolo | 2007 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CHR2/BDNF in their description or question text
No additional research found