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cell 511 words KG: NEURONS
Contents

TDP-43 Aggregate Neurons

🧫 Cell Type Info
Cell TypeNEURONS
Also Known AsNerve cell, Neuronal cell
FunctionsElectrical signal transmission, Synaptic neurotransmitter release, Neural circuit formation, Information processing and storage, Neuroendocrine signaling
Associated DiseasesAlzheimer's disease (neuronal loss), Parkinson's disease (dopaminergic neuron loss), ALS (motor neuron degeneration), Huntington's disease (striatal neuron loss), Epilepsy (hyperexcitability)
Related GenesALPHA-SYNUCLEIN, CD2AP, DRD2
Linked Hypotheses496 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (10)

Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Cryptic Exon Silencing Restoration
Score: 0.53Senescent Cell Mitochondrial DNA Release
Score: 0.74Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47...
Score: 0.68TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (16)

What determines the selectivity and efficiency of intercellu
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedWhat is the therapeutic window between insufficient and toxi
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (26)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95TDP-43 mitochondrial invasion and DNA release via mPTP
exploratory · proposed · Score: 0.90TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90cGAS/STING pathway validation in TDP-43 mutant mice
validation · proposed · Score: 0.85

Knowledge Graph (12 edges)

FERROPTOSIS associated_with NEURONS
L-DOPA associated_with NEURONS
APP associated_with NEURONS
PINK1 associated_with NEURONS
PARKIN associated_with NEURONS
GDNF associated_with NEURONS
NEURONS associated_with FIBROBLASTS
APOE associated_with NEURONS
AMYGDALA associated_with NEURONS
NEURONS associated_with EPILEPSY

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