concept

CD28

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD28: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

12Outgoing

5Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CD28
Key Genes/Proteins	APOE, CD14, CD24, CD4, CD8, CX3CR1
Related Pathways	TGF-beta signaling

Pathway Diagram

graph TD
    CD28[CD28]
    CD28 -->|expressed in| T_cells[T cells]
    CD28 -->|activates| CD4[CD4]
    CD28 -->|interacts| CD8[CD8]
    CD28 -->|interacts| CX3CR1[CX3CR1]
    CD28 -->|inhibits| TNF[TNF]
    CD28 -->|interacts| HLA[HLA]
    CD28 -->|participates in| TGF_beta_signaling[TGF-beta signaling]
    CD28 -->|data_in| benchmark_ot_ad_answer_key_CD2[benchmark_ot_ad_answer_key:CD28]
    FISETIN[FISETIN] -->|activates| CD28
    APOE[APOE] -->|expressed in| CD28
    CD14[CD14] -->|interacts| CD28
    CD24[CD24] -->|interacts| CD28
    benchmark_ot_ad_answer_key_CD2 -->|data_in| CD28

Outgoing (12)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD28	data_in	dataset_row	0.00
T cells	expressed_in	cell_type	0.70
TNF	inhibits	gene	0.60
CD4	activates	gene	0.60
HLA	interacts_with	gene	0.60
CD4	interacts_with	gene	0.60
CD8	interacts_with	gene	0.60
CX3CR1	interacts_with	gene	0.60
TGF	associated_with	gene	0.55
TGF-beta signaling	participates_in	pathway	0.55
CD4	associated_with	gene	0.55
FISETIN	associated_with	drug	0.45

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD28	data_in	dataset_row	0.00
FISETIN	activates	drug	0.65
CD24	interacts_with	gene	0.60
APOE	expressed_in	gene	0.60
CD14	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD28 in their description or question text

No additional research found