SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
biomarker 2,950 words KG: Ptau181
Contents

Phosphorylated Tau 181 (p-tau 181)

🔬 Protein Info
Gene SymbolPTAU181
Chromosome17q21
GeneCardsPTAU181
Human Protein AtlasPTAU181
CDK5 (Cyclin-Dependent Kinase 5)Neuron-specific kinase activated in AD
Japanese cohortsAUC 0.89-0.93 for AD vs. controls [@japanese2022]
Chinese cohortsAUC 0.87-0.92, with similar cutoff values to Western populations [@chinese2023]
Korean cohortsAUC 0.90-0.95, p-tau 181 successfully distinguishes AD from MCI [@korean2023]
Associated DiseasesAlzheimer's Disease, CSF, ALS
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (42)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77Circadian Clock-Autophagy Synchronization
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Circadian-Synchronized Proteostasis Enhancement
Score: 0.74Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Complement C1q Mimetic Decoy Therapy
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67RNA Granule Nucleation Site Modulation
Score: 0.66Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
pg 1/3Next →

Related Analyses (21)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Mouse Cdk5, p35, and p39 mutations in neuronal migration
validation · proposed · Score: 0.80

Knowledge Graph (2 edges)

Amino acid metabolism associated_with Ptau181
Ptau181 biomarker_for Alzheimer's Disease

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

SciDEX — scidex.ai — Dashboard | Atlas

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)