Contents

CSF Biomarker Comparison Across Neurodegenerative Diseases

🔬 Protein Info

Gene Symbol	CSF
What it measures	Synaptic degeneration
AD	Strongly elevated
PD	Mild elevation
ALS	Elevated
FTD	Variable
p-Tau181	Most established, AD-specific (sensitivity 85%, specificity 85%)[@hansson2022]
p-Tau217	Highest accuracy for AD (sensitivity 90%, specificity 88%)[@palmqvist2021]
p-Tau231	Earliest detector in preclinical AD[@janelidze2020]
Associated Diseases	MULTIPLE SCLEROSIS
Known Drugs/Compounds	ADUCANUMAB
KG Connections	134 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING