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mechanism 1,143 words KG: autophagy
Contents

Autophagy Dysfunction in Progressive Supranuclear Palsy

⚙ Mechanism Info
Nameautophagy
Key Genes/ProteinsACSL4, ADORA2A, ADRA2A, aggregate-prone proteins, Akt, AKT
Related Diseasesadipogenesis, age-related diseases
Related PathwaysAKT-MTOR, AKT signaling pathway
Linked Hypotheses21 hypotheses

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Knowledge Graph

Related Hypotheses (17)

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated
Score: 0.84Closed-loop tACS targeting entorhinal cortex layer II SST in
Score: 0.78TBK1 Loss Locks Microglia in an Aged/Senescent Transcription
Score: 0.78VCP/p97 ATPase mutations impair extraction of ubiquitinated
Score: 0.72Radiation drives pericyte senescence through lysosome acidif
Score: 0.65Mitophagy collapse via PINK1-PRKN is the primary autophagy l
Score: 0.61P2RY12-mediated autophagy inhibition in cerebral VSMCs impai
Score: 0.60Autophagy Activation ULK1/VPS34 (H3): Lipid Routing to Lysos
Score: 0.60P2RY12-driven autophagy impairment in cerebral VSMCs mediate
Score: 0.58Chronic mTORC1-ULK1 signaling blocks autophagy initiation in
Score: 0.58Synergistic enhancement of autophagy and lysosomal biogenesi
Score: 0.57HBOT (2.0 ATA, 60 min) activates TFEB-mediated autophagy-lys
Score: 0.56Dendritic tau missorting persists through local proteostatic
Score: 0.53Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediate
Score: 0.47Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Medi
Score: 0.45LRP1-Autophagy BBB Permeabilization for Antibody Transport
Score: 0.38P2RY12 rs2046934 polymorphism modifies neurodegeneration ris
Score: 0.27

Knowledge Graph (12 edges)

autophagy regulates ferroptosis
ULK1 activates autophagy
autophagy activates bacterial_clearance
autophagy activates NRF2
autophagy treats neurodegeneration
autophagy regulates intestinal_epithelium
autophagy regulates tight_junctions
autophagy activates barrier_function
autophagy regulates intestinal_stem_cells
autophagy regulates secretory_cells

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