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disease 1,073 words KG: C9orf72
Contents

Amyotrophic Lateral Sclerosis (ALS)

Disease Info
Associated GenesAMYOTROPHIC LATERAL SCLEROSIS
KG Connections81 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92CYP46A1 Overexpression Gene Therapy
Score: 0.92SASP-Mediated Complement Cascade Amplification
Score: 0.91Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedMicroglial subtypes in neurodegeneration — friend vs foe
neuroscience · archived

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

C9orf72 regulates MMP9
C9orf72 causes Frontotemporal dementia
C9orf72 causes lysosomal dysfunction
C9orf72 regulates TDP-43
CEREBELLUM associated_with C9orf72
C9orf72 interacts_with WDR41
C9orf72 involved_in Autoimmune Response
C9orf72 expressed_in presynaptic terminals
C9orf72 regulates dendritic arborization
C9orf72 expressed_in cerebellum

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