Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AAV-PHP.EB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | AAV-PHP.EB |
graph TD
AAV_PHP_EB[AAV-PHP.EB]
AAV_PHP_EB -->|targets| Central_Nervous_System[Central Nervous System]
AAV_PHP_EB -->|targets| Cortical_Neurons[Cortical Neurons]
AAV_PHP_EB -->|targets| Striatal_Neurons[Striatal Neurons]
AAV_PHP_EB -->|involved_in| central_nervous_system[central nervous system]
AAV_PHP_EB -->|involved_in| Intravenous_Administration[Intravenous Administration]
AAV_PHP_EB -->|involved_in| Gene_Transfer[Gene Transfer]
AAV_PHP_EB -->|mediates| gene_transfer[gene transfer]| Target | Relation | Type | Str |
|---|---|---|---|
| Central Nervous System | targets | process | 0.95 |
| Central Nervous System | targets | brain_region | 0.95 |
| Cortical Neurons | targets | cell_type | 0.92 |
| Cortical Neurons | transports | cell_type | 0.92 |
| Striatal Neurons | targets | cell_type | 0.92 |
| central nervous system | involved_in | brain_region | 0.92 |
| Striatal Neurons | transports | cell_type | 0.90 |
| Intravenous Administration | involved_in | process | 0.90 |
| Cell-Type-Specific Genetic Modification | associated_with | process | 0.88 |
| Gene Transfer | involved_in | process | 0.88 |
| gene transfer | mediates | process | 0.88 |
| Multicolor Labeling | associated_with | process | 0.85 |
| Cell Morphology Labeling | associated_with | process | 0.85 |
| blood-brain barrier | crosses | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression | 0.736 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
| AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal | 0.520 | neurodegeneration | epigenetic reprogramming aging neurons |
| FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expr | 0.380 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
| AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression | 0.359 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
| FUS-Enhanced AAV-PHP.eB Delivery of IGFBPL1 to Microglia | 0.338 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Focused ultrasound-mediated APOE4 knockdown in mouse brain. [PMID:40665471] | Zheng K, Tsitsos FN, Batts AJ, Ji R, Nur | Alzheimer's & dementia : the j | 2025 | 0 |
| Focused ultrasound widely broadens AAV-delivered Cas9 distribution and activity. [PMID:39893321] | Gumusgoz E, Kasiri S, Youssef I, Verma M | Gene therapy | 2025 | 0 |
| IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036] | Pan L, Cho KS, Wei X, Xu F, Lennikov A, | Cell reports | 2023 | 0 |
| Incisionless targeted adeno-associated viral vector delivery to the brain by foc [PMID:36152518] | Unknown | EBioMedicine | 2022 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning AAV-PHP.EB in their description or question text
No additional research found