| hyp-lyso-snca-3a610e | GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 Dopaminergic Neurons | 0.75 | 0.65 | TFEB | active | 2026-04-28 | |
| h-c704dd991041 | Tau/MAP6 ratio as a master switch for microtubule dynamics plasticity | 0.75 | 0.75 | MAPT | proposed | 2026-04-26 | paper-39257379 |
| h-e3557d75fa56 | Tau dysfunction destabilizes labile pool | 0.75 | 0.75 | MAPT | proposed | 2026-04-26 | paper-40040809 |
| h-dd0ccf93cb | Iron-driven lipid peroxidation and GPX4 failure create a ferroptotic amplificati | 0.75 | 0.78 | GPX4; SLC7A11; ACSL4; TFRC; FTH1; FTL | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate |
| h-16591043d1 | Selective blockade of classical-pathway activation downstream of C1q will reduce | 0.75 | 0.74 | C1QA,C1QB,C1QC,C1R,C1S,C4A,C4B,C3 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-afba1a80bd |
| h-2dd1b7359d | VHH-Fc Fusion Constructs with Separate BBB-Targeting Moiety | 0.75 | 0.72 | FCGRT (FcRn); FCGRT-β2M complex | proposed | 2026-04-22 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-immunity-6e54942b | Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate | 0.75 | 0.75 | C3, C3aR, NFKB1, PPARGC1A | open | 2026-04-24 | |
| h-var-799795f6af | TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming | 0.75 | 0.78 | TREM2, CSF1R | proposed | 2026-04-12 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-b98ff29728 | Gamma entrainment induces activity-dependent BDNF release to rescue NMJ and dend | 0.75 | 0.78 | BDNF (brain-derived neurotrophic factor); NTRK2 (TrkB); CREB | proposed | 2026-04-28 | SRB-2026-04-28-h-bdbd2120 |
| h-var-55da4f915d | Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma | 0.75 | 0.82 | SST | promoted | 2026-04-05 | SDA-2026-04-03-26abc5e5f9f2 |
| h-73e9899e | C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli | 0.75 | 0.68 | C1QA, C1QB | proposed | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3 |
| hyp-lyso-snca-c9e088 | GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reducing Miro | 0.75 | 0.68 | GBA1 | active | 2026-04-28 | |
| h-var-159030513d | Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Overexpression | 0.75 | 0.78 | NAMPT | promoted | 2026-04-12 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-SDA-2026-04-26-gap | Circulating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline | 0.74 | 0.27 | PDGFRβ | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-3156f6bcd349 | GPX4 reserve failure gates selective ALS motor-neuron ferroptosis | 0.74 | 0.72 | GPX4 | proposed | 2026-04-26 | SDA-2026-04-26-gap-ferroptosis-mnd-768eaeba1be3 |
| h-0e0cc0c1 | Circadian-Synchronized Proteostasis Enhancement | 0.74 | 0.60 | CLOCK/ULK1 | promoted | 2026-04-02 | sda-2026-04-01-gap-012 |
| h-var-59fc393ba6 | Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment | 0.74 | 0.78 | MAPT | proposed | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-ddd5c9bcc8 | TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging | 0.74 | 0.78 | TREM2 | proposed | 2026-04-12 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-seaad-fa5ea82d | APOE Isoform Expression Across Glial Subtypes | 0.74 | 0.55 | APOE | proposed | 2026-04-03 | analysis-SEAAD-20260402 |
| hyp-lyso-snca-3f4d11 | PD-Associated GWAS Variants in CTSO and CTSF Genes Create a Synthetic Lethal Int | 0.74 | 0.58 | GBA1 | active | 2026-04-28 | |
| h-a23cc3c8b9 | H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding | 0.74 | 0.78 | G3BP1, TARDBP, FUS | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad |
| h-73124693 | BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Intern | 0.74 | 0.72 | NRG1/ERBB4 | promoted | 2026-04-16 | SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2 |
| h-f9dca82e35 | Peripheral Monocyte/Macrophage Infiltration Mimicking Microglial Loss | 0.74 | 0.78 | CCR2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-072b2f5d | Smartphone-Detected Motor Variability Correction | 0.74 | 0.50 | DRD2/SNCA | promoted | 2026-04-02 | sda-2026-04-01-gap-012 |
| h-1a34778f | Senescent Cell Mitochondrial DNA Release | 0.74 | 0.50 | CGAS/STING1/DNASE2 | debated | 2026-04-02 | sda-2026-04-01-gap-013 |
| h-fd1562a3 | Near-infrared light therapy stimulates COX4-dependent mitochondrial motility enh | 0.74 | 0.50 | COX4I1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-c9c79e3e | APOE4-Selective Lipid Nanoemulsion Therapy | 0.74 | 0.60 | APOE | proposed | 2026-04-03 | sda-2026-04-01-gap-auto-fd6b1635d9 |
| h-1b47a73770 | APOE4-driven lysosome-to-ER cholesterol transport failure reduces ER-accessible | 0.74 | 0.79 | NPC1 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-f4c8357045 |
| h-180807e5 | APOE-TREM2 Interaction Modulation | 0.74 | 0.80 | TREM2 | promoted | 2026-04-03 | sda-2026-04-01-gap-auto-fd6b1635d9 |
| h-f4a63646 | Complement-SASP Amplification Cascade as Mechanistic Link | 0.74 | 0.65 | C1QA, C1QB, C3, IL1B, NFKB1 | promoted | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974 |
| h-d2722680 | Epigenetic Memory Erasure via TET2 Activation | 0.74 | 0.70 | TET2 | debated | 2026-04-02 | sda-2026-04-01-gap-007 |
| h-6726853448 | NRF2 failure lowers antioxidant reserve and permits recurrent mitochondrial ROS | 0.74 | 0.77 | NFE2L2; KEAP1; HMOX1; NQO1; GCLC; TXNRD1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate |
| h-cb692686e2 | Tau missorting transitions into an autonomous tau-seeding state after transient | 0.74 | 0.78 | MAPT | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-98a600b3ed |
| h-fc43140722 | Mutant-dependent amplification is context-dependent and strongest in microglia a | 0.74 | 0.75 | LRRK2,RAB10 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-9180363b7c |
| h-9bcba57f3f | VPS35 retromer activation prevents endosomal tau templating across all brain reg | 0.74 | 0.67 | VPS35 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| h-0b9e4152 | MEF2C-Dependent Synaptic Gene Regulation | 0.74 | 0.55 | MEF2C | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb |
| h-9b862d73ad | C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhibit Nucleocytoplasmi | 0.74 | 0.80 | NUP98 | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-fde8ac75360e | A tau PTM barcode gates trans-synaptic templating | 0.74 | 0.71 | MAPT | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f |
| h-69919c49 | PARP1 Inhibition Therapy | 0.74 | 0.50 | PARP1 | promoted | 2026-04-02 | sda-2026-04-01-gap-006 |
| h-ab41908b | Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determines AQP4 Tolerance | 0.74 | 0.55 | AHR, IL10, TNFRSF13B, TIGIT, FOXP3 | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b |
| h-seaad-v4-5a7a4079 | SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy D | 0.74 | 0.62 | SIRT3 | debated | 2026-04-03 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-0c2927c851 | H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules | 0.74 | 0.72 | TBK1, SQSTM1/p62, OPTN, NDP52 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad |
| h-SDA-2026-04-26-gap | Ultra-Low Physiological Replacement Dosing for Long-Term Prevention | 0.73 | 0.57 | MT1/ERK1/2 (MAPK1/3); Nrf2 (NFEL2L2); BACE1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-090734-1be1b913 |
| h-SDA-2026-04-26-gap | Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Blood as an Early Indi | 0.73 | 0.18 | MMP-9 (Matrix Metallopeptidase 9) / TIMP-1 ratio | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc |
| h-7210c29bb9 | Metabolic Inflexibility Precedes Transcriptional Reprogramming (NAD+/SIRT3 Axis) | 0.73 | 0.68 | SIRT3/NAD+ salvage pathway, PGC-1α | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-7a6cf14e |
| h-15a8468c | TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies | 0.73 | 0.72 | TREM2, TYROBP (DAP12), PLCG2, SYK | promoted | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974 |
| h-trem2-6a46fa2c | Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Anta | 0.73 | 0.60 | TREM2, APOE, MAPT | proposed | 2026-04-05 | SDA-2026-04-02-gap-001 |
| h-a6e77292 | SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via | 0.73 | 0.72 | SGMS1, BECN1 | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32 |
| h-1a4820f3 | Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S | 0.73 | 0.30 | miR-6361 seed-proximal binding site (lncRNA-0021 coordinates | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac |
| hyp-lyso-snca-548064 | SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents TorsinA-Mediated LAMP2A | 0.73 | 0.62 | LAMP2 | active | 2026-04-28 | |