| hyp-SDA-2026-04-12-2 | Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid Pathology | 0.79 | 0.55 | CHRNA7 (α7 nicotinic receptor), BACE1 | debated | 2026-04-13 | SDA-2026-04-12-20260411-082446-2c1c9e2d |
| h-d0a564e8 | Competitive APOE4 Domain Stabilization Peptides | 0.78 | 0.30 | APOE | promoted | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-ecd9ed6c | Integrated Biomarker Panel for Therapeutic Window Identification | 0.78 | 0.68 | CHI3L1 | promoted | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112330-9abf86eb |
| h-var-d98a992599 | Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa | 0.78 | 0.72 | SST | proposed | 2026-04-05 | SDA-2026-04-03-26abc5e5f9f2 |
| hyp-lyso-snca-1d58cf | LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergic Neurons Create Sel | 0.78 | 0.68 | LAMP2 | active | 2026-04-28 | |
| h-01685bc3b9 | Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46) | 0.78 | 0.72 | CD55 (DAF), CD46 (MCP) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| h-807d7a82 | SASP-Driven Aquaporin-4 Dysregulation | 0.78 | 0.70 | AQP4 | promoted | 2026-04-02 | sda-2026-04-01-gap-013 |
| h-de0d4364 | Selective Acid Sphingomyelinase Modulation Therapy | 0.78 | 0.80 | SMPD1 | promoted | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| SDA-2026-04-02-gap-t | TREM2-mediated microglial tau clearance enhancement | 0.78 | 0.67 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-cross-synth-stress | Stress-granule RNA-binding protein phase transition across ALS and FTD | 0.78 | 0.74 | TIA1;HNRNPA1;HNRNPA2B1 | active | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-9923279def | PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifies PD (SNCA/αSyn) and | 0.78 | 0.72 | PINK1,PRKN,TREM2,STUB1,NDUFS7 | proposed | 2026-04-28 | |
| h-7000ac15c1 | Therapeutic Window Exists Because Amplified Signals (Not Baseline) Drive Pathoge | 0.78 | 0.78 | LRRK2 | proposed | 2026-04-26 | SDA-2026-04-23-gap-debate-20260417-033119-54941818 |
| h-dec9f2e970 | NLRP3 Inhibition (H7): Downstream Inflammatory Reversal | 0.78 | 0.78 | NLRP3/NLRP3 (NLRP3 inflammasome) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-17d177c62b | Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Reducing | 0.78 | 0.78 | AQP4, orexin receptor (HCRTR1/2) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-7bcf4b6c |
| h-810ec0eb | TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis | 0.78 | 0.52 | TFEB, MTOR | promoted | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88 |
| h-var-f96e38ec20 | ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie | 0.78 | 0.82 | ACSL4 | superseded | 2026-04-05 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-0e675a41 | Selective HDAC3 Inhibition with Cognitive Enhancement | 0.78 | 0.80 | HDAC3 | promoted | 2026-04-02 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-26b9f3e7 | SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against Microb | 0.78 | 0.76 | SIRT1, PGC-1α (PPARGC1A), NAMPT | promoted | 2026-04-17 | SDA-BIOMNI-MICROBIO-337ee37a |
| h-ae1b2beb | Transcriptional Autophagy-Lysosome Coupling | 0.78 | 0.71 | FOXO1 | promoted | 2026-04-02 | sda-2026-04-01-gap-011 |
| h-var-600b3e39aa | APOE4-Specific Proteolytic Fragment Inhibition Therapy | 0.78 | 0.65 | APOE | proposed | 2026-04-16 | |
| h-var-e4cae9d286 | LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine | 0.78 | 0.82 | LPCAT3 | debated | 2026-04-05 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| hyp-lyso-snca-3429d8 | Exosomal SNCA Propagation from Lysosome-Compromised Neurons Contains a Distinct | 0.78 | 0.70 | SNCA | active | 2026-04-28 | |
| h-cross-synth-tbk1-o | TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, and PD-like proteotox | 0.78 | 0.73 | TBK1 | active | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-7597968b | CX3CR1-TREM2 Integration for Synapse Pruning Normalization | 0.78 | 0.52 | CX3CR1-TREM2 | proposed | 2026-04-17 | SDA-2026-04-01-gap-001 |
| h-var-c56b26facf | LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Dise | 0.78 | 0.82 | LPCAT3 | debated | 2026-04-05 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-62f9fc90 | Prefrontal sensory gating circuit restoration via PV interneuron enhancement | 0.78 | 0.75 | PVALB | promoted | 2026-04-02 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-787aa9d1b4 | Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical mem | 0.77 | 0.78 | SST | promoted | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-028af077 | miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy | 0.77 | 0.75 | miR-33/ABCA1 | promoted | 2026-04-16 | SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e |
| h-var-8412ce00a4 | Dual-Circuit Tau Vulnerability Cascade | 0.77 | 0.75 | MAPT | promoted | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-trem2-f48baa0c | TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearanc | 0.77 | 0.67 | TREM2, APOE | proposed | 2026-04-05 | SDA-2026-04-02-gap-001 |
| h-6df1bc66 | Biphasic Ketogenic Intervention Protocol | 0.77 | 0.50 | HMGCS2 | proposed | 2026-04-17 | SDA-2026-04-03-gap-debate-20260403-222618-2709aad9 |
| h-23a3cc07 | Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation | 0.77 | 0.30 | FCGRT | promoted | 2026-04-02 | sda-2026-04-01-gap-008 |
| h-c90cca1826 | Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake | 0.77 | 0.78 | SULF1/SULF2 | proposed | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-var-97b18b880d | ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidat | 0.77 | 0.82 | ALOX15 | debated | 2026-04-05 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-c1d5dcbf48 | TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy | 0.77 | 0.78 | TBK1, OPTN (TBC1D7), NDP52/CALCOCO2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-89f1963f | Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway | 0.77 | 0.42 | GPNMB, CD44 | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-170057-a2f72fd8 |
| h-6fe30c39bc | STING Antagonists as ALS Therapeutics: Drug Repurposing | 0.77 | 0.68 | STING (TMEM173) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-c58ac188fc | Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation | 0.77 | 0.82 | TREM2 | debated | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-eb7e85343b | H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasi | 0.77 | 0.78 | SIRT1, NAMPT, NAD+ salvage pathway | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-af0ec8d843 | Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzhe | 0.77 | 0.82 | C1Q | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| SDA-2026-04-16-hyp-b | Oligodendrocyte Precursor Cell Senescence in White Matter Disease | 0.77 | 0.60 | CSPG4,OLIG2,BCL2 | proposed | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| hyp-SDA-2026-04-12-2 | Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling | 0.77 | 0.65 | CHRNA7, CHRM1 | debated | 2026-04-13 | SDA-2026-04-12-20260411-082446-2c1c9e2d |
| h-addc0a61 | Chromatin Accessibility Restoration via BRD4 Modulation | 0.77 | 0.60 | BRD4 | promoted | 2026-04-02 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-2600483e | CYP46A1 Overexpression Gene Therapy | 0.77 | 0.85 | CYP46A1 | promoted | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-25580e2e | Lysosomal Cathepsin-Dependent Tau Clearance | 0.77 | 0.45 | | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150544-e3a2eab9 |
| h-var-ea70ada256 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.77 | 0.78 | SST | proposed | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-ed8dee29 | HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention | 0.77 | 0.62 | ABCA1 | proposed | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-083043-759b4c5e |
| h-c49c08c56a | Kinetic Modeling Predicts Threshold-Dependent Efficacy—Early Intervention Requir | 0.77 | 0.72 | Seed amplification threshold (RT-QuIC diagnostic) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-44195347 | APOE4 Allosteric Rescue via Small Molecule Chaperones | 0.76 | 0.40 | APOE | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-var-a09491064e | Chromatin Remodeling-Mediated Nutrient Sensing Restoration | 0.76 | 0.82 | SMARCA4 | promoted | 2026-04-12 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |