| h-a6e77292 | SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysosomal Degradation via | 0.73 | 0.72 | SGMS1, BECN1 | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32 |
| h-1a4820f3 | Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S | 0.73 | 0.30 | miR-6361 seed-proximal binding site (lncRNA-0021 coordinates | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac |
| hyp-lyso-snca-548064 | SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents TorsinA-Mediated LAMP2A | 0.73 | 0.62 | LAMP2 | active | 2026-04-28 | SRB-2026-04-29-hyp-lyso-snca-54 |
| h-c8ccbee8 | Aquaporin-4 Polarization Rescue | 0.73 | 0.68 | AQP4 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-796cfd1c | SMPD1 (Acid Sphingomyelinase) Inhibition for Ceramide Reduction and BACE1 Regula | 0.73 | 0.75 | SMPD1 | promoted | 2026-04-16 | SDA-2026-04-15-gap-debate-20260410-112819-e40e0fa2 |
| h-bb518928 | Senescence-Associated Myelin Lipid Remodeling | 0.73 | 0.30 | PLA2G6/PLA2G4A | debated | 2026-04-02 | sda-2026-04-01-gap-013 |
| h-var-f354525002 | Selective Neutral Sphingomyelinase-2 Inhibition Therapy | 0.73 | 0.30 | SMPD3 | promoted | 2026-04-12 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-7957bb2a | Senescence-Induced Lipid Peroxidation Spreading | 0.73 | 0.40 | GPX4/SLC7A11 | debated | 2026-04-02 | sda-2026-04-01-gap-013 |
| h-a0269f3c81 | G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanced RAB29-Dependent R | 0.73 | 0.72 | LRRK2,RAB29 | proposed | 2026-04-26 | SDA-2026-04-23-gap-debate-20260417-033119-54941818 |
| h-083d94e34b | Metabolic-Support Secretome Dysfunction | 0.73 | 0.75 | HIF1A; SLC16A2 (MCT2); LDHA | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-8254c04dfd | Endosomal trafficking defects are the common upstream lesion linking APP process | 0.73 | 0.25 | SORL1, BIN1, PICALM, VPS35, APP, NTRK1 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-e849205bca |
| h-26353f7f59 | Temporal order is subtype-specific rather than universal | 0.73 | 0.76 | APOE, SORL1, NTRK1, BIN1, PICALM | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-e849205bca |
| h-08ca25f232 | H1: T-Type Calcium Channel–Driven Calcium Overload and Proteostasis Collapse | 0.73 | 0.72 | CACNA1H (Cav3.2), CAPN2, PPP2R2D | proposed | 2026-04-22 | SDA-2026-04-02-gap-ec-layer2-vulnerability |
| h-9c5abf9343 | Ubiquitin-Mediated Liquid-to-Solid Transition Prevention | 0.73 | 0.78 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-41bc2d38 | Adenosine-Astrocyte Metabolic Reset | 0.73 | 0.65 | ADORA2A | promoted | 2026-04-02 | sda-2026-04-01-gap-v2-18cf98ca |
| h-ec731b7a | Phase-Separated Organelle Targeting | 0.73 | 0.80 | G3BP1 | debated | 2026-04-02 | sda-2026-04-01-gap-009 |
| h-6ea2dc4c96 | SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysregulation | 0.73 | 0.82 | GPR43 (FFAR2), GPR41 (FFAR3), HDAC3, RELA (NF-κB p65) | debated | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-54c6dd37ce | TFEB/TFE3 Parallel Activation Drives Coordinated Organelle Clearance via CLEAR N | 0.73 | 0.70 | TFEB (TFEB), TFE3 (TFE3), mTORC1 (MTOR) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-84808267 | Synthetic Biology BBB Endothelial Cell Reprogramming | 0.73 | 0.60 | TFR1, LRP1, CAV1, ABCB1 | debated | 2026-04-02 | sda-2026-04-01-gap-008 |
| h-a1b56d74 | Metabolic Switch Targeting for A1→A2 Repolarization | 0.73 | 0.55 | HK2 | debated | 2026-04-02 | sda-2026-04-01-gap-007 |
| h-3616325a | Microglial TREM2-Complement Axis Modulation | 0.73 | 0.80 | TREM2 and C3 | promoted | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-98b431ba | TFAM overexpression creates mitochondrial donor-recipient gradients for directed | 0.73 | 0.60 | TFAM | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-8fe389e8 | Astrocyte-Mediated Neuronal Epigenetic Rescue | 0.73 | 0.65 | HDAC | debated | 2026-04-02 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-SDA-2026-04-26-gap | Calcium-Dependent S100B Release from Astrocyte End-Feet as an Early Signal of As | 0.72 | 0.49 | S100B (S100 Calcium Binding Protein B) | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc |
| h-6f6c9d3c | TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc | 0.72 | 0.72 | TARDBP (TDP-43 protein); IPO4/IP09 (nuclear import receptors | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| h-5d943bfc | Proteostasis Enhancement via APOE Chaperone Targeting | 0.72 | 0.65 | HSPA1A | proposed | 2026-04-03 | sda-2026-04-01-gap-auto-fd6b1635d9 |
| h-b9f5438c | TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I | 0.72 | 0.60 | TBK1 | proposed | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-165527-8256a071 |
| h-8a244611 | Context-Dependent Cx43 Modulation Based on Disease Stage | 0.72 | 0.52 | GJA1 (Cx43) - context-dependent | promoted | 2026-04-13 | SDA-2026-04-12-gap-debate-20260410-113038-57244485 |
| h-25ec762b3f | CSF YKL-40 as a Priming-Specific Chitinase Marker | 0.72 | 0.72 | CHI3L1/YKL-40 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-99b4e2d2 | Interfacial Lipid Mimetics to Disrupt Domain Interaction | 0.72 | 0.68 | APOE | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-5706bbd7 | Circadian Rhythm Entrainment of Reactive Astrocytes | 0.72 | 0.50 | BMAL1 | debated | 2026-04-02 | sda-2026-04-01-gap-007 |
| h-1eaa052225 | Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in A | 0.72 | 0.30 | TREM2 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-8d270062 | Sleep Spindle-Synaptic Plasticity Enhancement | 0.72 | 0.45 | CACNA1G | debated | 2026-04-02 | sda-2026-04-01-gap-v2-18cf98ca |
| h-a1552ac3 | LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-Driven Myelin Defici | 0.72 | 0.72 | NR1H2 (LXRβ) | promoted | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260410-193244-89904941 |
| h-056cb87f4e | NLRP3 Inflammasome Inhibition for Neuroprotection in Parkinson's Disease | 0.72 | 0.72 | NLRP3 | proposed | 2026-04-29 | SDA-2026-04-28-gap-test-20260425-224949 |
| h-b76cedd571 | Microglia-Mediated Neuroinflammation as a Disease-Amplifying Mechanism | 0.72 | 0.72 | NLRP3, TREM2, TYROBP, CX3CR1 | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-72c719461c | C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD | 0.72 | 0.88 | C9orf72 | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-51302631b4 | APOE4-driven pericyte injury/senescence is an upstream driver of early BBB break | 0.72 | 0.78 | APOE4, LRP1, PPIA, MMP9, PDGFRB | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-de5dfc4391 |
| h-90b7b77f59 | Bacterial Curli Amyloid → Nucleation of α-Synuclein Misfolding in Enteric Neuron | 0.72 | 0.72 | CsgA, CsgB, CsgC, α-synuclein (SNCA) | proposed | 2026-04-22 | sda-2026-04-01-gap-20260401-225155 |
| h-a5bc82c685 | Excessive C1q/C3/CR3 complement cascade activation initiates pre-symptomatic syn | 0.72 | 0.72 | C1QA, C1QB, C1QC, C3, ITGAM/ITGAX | proposed | 2026-04-22 | SDA-2026-04-02-gap-synaptic-pruning-microglia |
| h-9ff41c2036 | H6: Layer II–Specific Loss of NPTX2 and Aberrant AMPAR Trafficking | 0.72 | 0.75 | NPTX2, ARC | proposed | 2026-04-22 | SDA-2026-04-02-gap-ec-layer2-vulnerability |
| h-c410043ac4 | Antisense Oligonucleotide-Mediated APOE4 Haploinsufficiency | 0.72 | 0.75 | APOE | proposed | 2026-04-22 | SDA-2026-04-02-gap-apoe4-targeting |
| h-a352af801c | SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/MMP-3 Ratio | 0.72 | 0.75 | CXCL1, CXCL2, MMP3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-7af6de6f2a | NLRP3 Inflammasome Lock Perpetuates Senescence-Associated Inflammasome Phenotype | 0.72 | 0.72 | NLRP3/CASP1/IL1B | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-641ea3f1a7 | H3: APOE4 Impairs Cholesterol Trafficking, Triggering Astrocyte Senescence | 0.72 | 0.72 | ABCA1/ABCG1; LXR (NR1H3) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0 |
| h-5258e4d0ee | Autophagic Receptor Sequestration via K63-Ub 'Signalone' Recognition | 0.72 | 0.25 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-fca0433042 | Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplification | 0.72 | 0.70 | IFNAR1/IFNAR2, STING (TMEM173), cGAS (CGAS) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-d4e73cf08f | VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates | 0.72 | 0.72 | VCP | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| SDA-2026-04-16-hyp-e | Metabolic Reprogramming to Reverse Senescence | 0.72 | 0.79 | SIRT1,PGC1A,NAMPT | promoted | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-6756097b | ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis | 0.72 | 0.68 | FUS | promoted | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260410-184155-2ff305ca |