| sess_SDA-2026-04-12- | What is the actual quantitative contribution of FcRn-mediated transcytosis to BB | 0.91 | 7 | 6 | completed | 2026-04-12 | SDA-2026-04-12-gap-debate-20260410-112908-13c403ee |
| sess_sda-2026-04-01- | TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small | 0.84 | 7 | 6 | completed | 2026-04-12 | sda-2026-04-01-gap-006 |
| sess_SDA-2026-04-03- | Does neuroplasticity decline with age? | 0.50 | 0 | 6 | enrolling | 2026-04-11 | |
| DA-2026-04-11-093252 | TDP-43 phase separation therapeutics for ALS-FTD | 0.34 | 0 | 6 | enrolling | 2026-04-11 | |
| DA-2026-04-03-001 | What are novel CRISPR-based therapies for Huntington's disease? | 0.50 | 0 | 7 | enrolling | 2026-04-11 | |
| debate-test-enrollme | Does neuroplasticity decline with age? | 0.50 | 0 | 6 | enrolling | 2026-04-11 | |
| debate-test-gap-enro | Test debate on neuroplasticity mechanisms | 0.50 | 0 | 6 | enrolling | 2026-04-11 | |
| sess_SDA-2026-04-11- | Does reduced Prevotellaceae abundance cause PD pathology or result from it? | 0.95 | 7 | 4 | completed | 2026-04-11 | SDA-2026-04-11-gap-debate-20260410-111558-f9487fea |
| sess_SDA-2026-04-01- | Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c | 0.93 | 7 | 5 | completed | 2026-04-11 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| sess_SDA-2026-04-11- | TDP-43 phase separation therapeutics for ALS-FTD | 0.95 | 7 | 4 | completed | 2026-04-11 | sda-2026-04-01-gap-006 |
| sess_SDA-2026-04-04- | How do alterations in brain lipid metabolism—including gangliosides, phospholipi | 0.84 | 6 | 4 | completed | 2026-04-11 | SDA-2026-04-04-frontier-lipidomics-dcdbc360 |
| sess_SDA-2026-04-04- | How do peripheral immune system alterations influence CNS pathology and neurodeg | 0.50 | 0 | 4 | completed | 2026-04-11 | SDA-2026-04-04-frontier-immunomics-e6f97b29 |
| sess_SDA-2026-04-04- | How do structural and functional connectivity changes in the human brain connect | 0.44 | 0 | 4 | completed | 2026-04-11 | SDA-2026-04-04-frontier-connectomics-84acb35a |
| sess_SDA-2026-04-04- | What are the critical protein expression changes and post-translational modifica | 0.56 | 0 | 4 | completed | 2026-04-11 | SDA-2026-04-04-frontier-proteomics-1c3dba72 |
| sess_SDA-2026-04-04- | Epigenetic reprogramming in aging neurons | 0.95 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| sess_SDA-2026-04-08- | The abstract identifies tissue-specific networks that may underlie Mendelian dis | 0.95 | 7 | 6 | completed | 2026-04-10 | SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522 |
| sess_SDA-2026-04-08- | While the abstract mentions identifying subcellular roles of protein interaction | 0.95 | 7 | 7 | completed | 2026-04-10 | SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47 |
| sess_SDA-2026-04-08- | The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into | 0.90 | 7 | 7 | completed | 2026-04-10 | SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca |
| sess_SDA-2026-04-08- | How do host cell factors influence the conformation and propagation properties o | 0.95 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-08-gap-pubmed-20260406-062207-b800e5d3 |
| sess_SDA-2026-04-08- | While the study shows 53BP1 forms phase-separated foci driven by dilncRNAs, it's | 0.95 | 7 | 7 | completed | 2026-04-10 | SDA-2026-04-08-gap-pubmed-20260406-062229-3ab00c95 |
| sess_gut-brain-ad | Gut-Brain Axis Therapeutics for Alzheimer's Disease? | 0.94 | 7 | 4 | completed | 2026-04-10 | gut-brain-ad |
| sess_sda-2026-04-01- | Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique | 0.95 | 7 | 6 | completed | 2026-04-10 | sda-2026-04-01-gap-004 |
| sess_sda-2026-04-01- | PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns | 0.91 | 7 | 7 | completed | 2026-04-10 | sda-2026-04-01-gap-005 |
| sess_SDA-2026-04-10- | How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa | 0.94 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-08-gap-pubmed-20260406-062212-b66510d9 |
| sess_SDA-2026-04-10- | Can circadian interventions reverse microglial priming independent of sleep disr | 0.95 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-08-gap-debate-20260406-062033-16eccec1 |
| sess_SDA-2026-04-10- | Do different priming stimuli require distinct therapeutic approaches or share co | 0.93 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-08-gap-debate-20260406-062039-f02efa4b |
| sess_SDA-2026-04-10- | What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie | 0.86 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-09-gap-debate-20260409-201742-5407d57d |
| sess_SDA-2026-04-10- | Do tau-containing vesicles exhibit unique surface glycosylation patterns that di | 0.95 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-09-gap-debate-20260409-201742-d279750b |
| sess_SDA-2026-04-10- | Which specific post-translational modifications on pathological tau create drugg | 0.50 | 0 | 4 | completed | 2026-04-10 | SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd |
| sess_SDA-2026-04-10- | Can nanobodies achieve selective membrane penetration into tau-containing vesicl | 0.95 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1 |
| sess_SDA-2026-04-10- | TREM2 Therapeutic Strategy Post-INVOKE-2? | 0.95 | 7 | 4 | completed | 2026-04-10 | trem2-ad |
| sess_SDA-2026-04-10- | Astrocyte reactivity subtypes in neurodegeneration | 0.95 | 7 | 4 | completed | 2026-04-10 | sda-2026-04-01-gap-007 |
| sess_SDA-2026-04-10- | GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease? | 0.89 | 7 | 4 | completed | 2026-04-10 | gba-pd |
| sess_SDA-2026-04-08- | The debate noted clinical failures of TNF-α and IL-6 inhibitors in AD despite th | 0.79 | 7 | 4 | completed | 2026-04-10 | SDA-2026-04-08-gap-debate-20260406-062045-ce866189 |
| sess_SDA-2026-04-08- | The debate identified fundamental druggability challenges for these targets due | 0.95 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd |
| sess_SDA-2026-04-08- | The highest-ranked hypothesis assumes senescence reversibility through metabolic | 0.95 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-debate-20260406-062101-7751c220 |
| sess_SDA-2026-04-08- | The authors identify SPI1 as a potential transcription factor regulating the hub | 0.93 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-pubmed-20260406-062122-bfac06c8 |
| sess_SDA-2026-04-08- | The study reports that complement-mediated synaptic elimination produces both co | 0.83 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-pubmed-20260406-062128-34a47c4e |
| sess_SDA-2026-04-08- | While the abstract establishes that intercellular transmission occurs for variou | 0.95 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-pubmed-20260406-062207-5a703c17 |
| sess_SDA-2026-04-08- | The study identifies ADCY8 as associated with migratory distance differences and | 0.95 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-pubmed-20260406-062218-580b17ef |
| sess_SDA-2026-04-08- | While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w | 0.92 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-debate-20260406-062033-fecb8755 |
| sess_SDA-2026-04-08- | The abstract notes that clinical presentations overlap across different myelopat | 0.86 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-pubmed-20260406-062111-db808ee9 |
| sess_SDA-2026-04-08- | The paper describes memory-based migration routes maintained across generations | 0.95 | 7 | 4 | completed | 2026-04-09 | SDA-2026-04-08-gap-pubmed-20260406-062218-5c7f15f4 |
| sess_astrocyte-subty | Astrocyte Reactivity Subtypes in Neurodegeneration | 0.95 | 7 | 4 | completed | 2026-04-09 | astrocyte-subtypes |
| sess_sda-2026-04-01- | Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi | 0.91 | 7 | 4 | completed | 2026-04-07 | sda-2026-04-01-gap-008 |
| sess_sda-2026-04-01- | Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee | 0.90 | 7 | 4 | completed | 2026-04-07 | sda-2026-04-01-gap-009 |
| sess_sda-2026-04-01- | APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b | 0.89 | 7 | 4 | completed | 2026-04-07 | sda-2026-04-01-gap-010 |
| sess_sda-2026-04-01- | Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th | 0.90 | 7 | 4 | completed | 2026-04-07 | sda-2026-04-01-gap-011 |
| sess_sda-2026-04-01- | Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene | 0.95 | 7 | 4 | completed | 2026-04-07 | sda-2026-04-01-gap-012 |
| sess_sda-2026-04-01- | Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP | 0.89 | 7 | 4 | completed | 2026-04-07 | sda-2026-04-01-gap-013 |