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Debates

882 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
sess_SDA-2026-04-13-The finding that Mertk/Axl deficiency increases viral susceptibility contradicts0.7404completed2026-04-16SDA-2026-04-13-gap-pubmed-20260410-174607-708e8d91
sess_SDA-2026-04-14-The study shows that OB microglia phagocytose LC axons before amyloid plaque for0.7004completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-181258-df5eee45
sess_SDA-2026-04-14-The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-191132-d67a1191
sess_SDA-2026-04-14-The abstract reports that pericyte senescence contributes to glioma growth and i0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-193006-09757220
sess_SDA-2026-04-14-Both compounds similarly reduced aging hallmarks (AMPK, Nrf2, COX IV1) and infla0.6804completed2026-04-16SDA-2026-04-14-gap-pubmed-20260411-065157-53c2c658
sess_SDA-2026-04-15-The abstract shows that Gal3 binding to pTau greatly enhances tau fibrillation, 0.9274completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-080155-ea072afc
sess_SDA-2026-04-14-The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260411-075338-35f913fb
sess_SDA-2026-04-15-The abstract shows that damaged mitochondrial inner membranes appear early in PL0.9574completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-082435-2ccbb742
sess_SDA-2026-04-15-While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th0.8074completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112528-782f5aa2
sess_SDA-2026-04-15-The debate assumed static 5-hydroxymethylcytosine patterns in aging neurons are 0.9574completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112539-31f47880
sess_SDA-2026-04-15-All participants identified brain delivery as a critical barrier, but no mechani0.5004completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112545-377c1d9e
sess_SDA-2026-04-15-test debate [TARGET_ARTIFACT type=experiment id=exp-123]0.9574completed2026-04-16SDA-2026-04-15-gap-20260415-221737
sess_SDA-2026-04-15-Does APOE4 drive tau propagation [TARGET_ARTIFACT type=hypothesis id=TEST-123]0.6404completed2026-04-16SDA-2026-04-15-gap-20260415-222947
sess_SDA-2026-04-16-Blood-brain barrier tight junction disruption by neuroinflammatory cytokines0.8777completed2026-04-16SDA-2026-04-16-gap-bbb-tjp-20260416041707
sess_SDA-2026-04-16-Does APOE4 drive tau propagation [TARGET_ARTIFACT type=hypothesis id=TEST-123]0.6804completed2026-04-16SDA-2026-04-16-gap-20260415-222947
sess_SDA-2026-04-14-The abstract explicitly states the critical need to identify genetic risk factor0.5804completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-185318-186b0446
sess_SDA-2026-04-14-The observation that salsalate and diflunisal decrease both AD and TBI incidence0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-184233-98bf553f
sess_SDA-2026-04-14-The abstract reveals FUS has a chaperone-like function regulating TAZ condensate0.8154completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-184155-2ff305ca
sess_SDA-2026-04-14-This study shows APOE4 carriers have enhanced beneficial innate immune responses0.6004completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-184126-b2c3e2e8
sess_SDA-2026-04-14-The abstract identifies APOE4's primary effect on oligodendrocyte cholesterol me0.6934completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-193244-89904941
sess_SDA-2026-04-14-The abstract reveals contradictory evidence where clusterin is proposed as a pro0.7234completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-193701-11582758
sess_SDA-2026-04-15-The debate revealed contradictory evidence about CD8+ T cell roles in neurodegen0.7634completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112400-454036f1
sess_SDA-2026-04-15-The debate raised whether SST/PV interneuron dysfunction represents adaptive com0.7634completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3
sess_SDA-2026-04-15-Despite the debate focusing on SEA-AD transcriptomic data, no actual gene expres0.7634completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112607-0a3749ea
sess_SDA-2026-04-15-The debate established that ceramide accumulation affects amyloid-β processing b0.8434completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112819-e40e0fa2
sess_SDA-2026-04-15-The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap0.7134completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb
sess_SDA-2026-04-15-This finding contradicts the established paradigm that autophagy is generally pr0.7434completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-075356-20920528
sess_SDA-2026-04-15-The study demonstrates that apoE is absolutely required for CAA development, as 0.7134completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-083043-759b4c5e
sess_SDA-2026-04-15-The study demonstrates that SGMS1 elevation correlates with increased Aβ and tha0.7534completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32
sess_SDA-2026-04-15-This study reveals SYNGAP1 expression and function in radial glia before synapto0.7834completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c
sess_SDA-2026-04-15-The abstract shows p53 is a central regulator of C9orf72-mediated neurodegenerat0.6134completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-090658-7651c1d2
sess_SDA-2026-04-15-The abstract identifies BACE1 as an attractive drug target but doesn't address i0.7634completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2
sess_SDA-2026-04-14-The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-183548-043c7918
sess_SDA-2026-04-14-The abstract describes a counterintuitive finding where loss-of-function P/Q mut0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-181156-feec7bd3
sess_SDA-2026-04-15-The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept0.9574completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-093924-7330920b
sess_SDA-2026-04-15-The study shows deferiprone rescues wild-type cells but exacerbates toxicity in 0.9574completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977
sess_SDA-2026-04-15-The abstract reveals an unexpected contradiction where PRKN activation, normally0.9174completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-082509-118fcb37
sess_SDA-2026-04-15-The abstract shows that acute neuroinflammation becomes persistent with a specif0.8374completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c
sess_SDA-2026-04-15-The abstract challenges the rationale for using microtubule-stabilizing drugs in0.6804completed2026-04-16SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d
sess_SDA-2026-04-15-The debate highlighted tau prion-like transmission but did not resolve how diffe0.5704completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112730-24052bbe
sess_SDA-2026-04-15-While TREM2 was identified as critical for microglial senescence, the debate lac0.7344completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f
sess_SDA-2026-04-14-The abstract shows TYROBP deficiency is neuroprotective despite being required f0.5604completed2026-04-16SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c
sess_SDA-2026-04-14-The study demonstrates that exercise-conditioned plasma transfers cognitive bene0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-191046-15921012
sess_SDA-2026-04-14-The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex0.6604completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04
sess_SDA-2026-04-02-0.9574completed2026-04-16SDA-2026-04-02-gap-v2-e1e1b7c3
sess_SDA-2026-04-14-The study shows dramatic functional recovery and muscle re-innervation after cyt0.8574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917
sess_SDA-2026-04-14-The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mi0.6004completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8
sess_SDA-2026-04-14-The finding that Mertk/Axl deficiency increases viral susceptibility contradicts0.7504completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91
sess_SDA-2026-04-15-The debate identified a critical therapeutic window when astrocytic ketone produ0.8534completed2026-04-15SDA-2026-04-15-gap-debate-20260410-112330-9abf86eb
sess_SDA-2026-04-15-What molecular mechanisms mediate SPP1-induced microglial phagocytic activation 0.9575completed2026-04-15SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
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